Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 788190..788850 Replicon chromosome
Accession NZ_CP093390
Organism Salmonella enterica strain P289597

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag MOV19_RS03820 Protein ID WP_000244761.1
Coordinates 788437..788850 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MOV19_RS03815 Protein ID WP_000351186.1
Coordinates 788190..788456 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV19_RS03795 (784118) 784118..785551 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
MOV19_RS03800 (785710) 785710..786021 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MOV19_RS03805 (786185) 786185..786844 + 660 WP_000250289.1 hemolysin III family protein -
MOV19_RS03810 (786960) 786960..787940 - 981 WP_000874166.1 tRNA-modifying protein YgfZ -
MOV19_RS03815 (788190) 788190..788456 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MOV19_RS03820 (788437) 788437..788850 + 414 WP_000244761.1 protein YgfX Toxin
MOV19_RS03825 (788903) 788903..789424 - 522 WP_001055885.1 flavodoxin FldB -
MOV19_RS03830 (789537) 789537..790433 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MOV19_RS03835 (790457) 790457..791170 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOV19_RS03840 (791176) 791176..792909 + 1734 WP_086126359.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T238375 WP_000244761.1 NZ_CP093390:788437-788850 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T238375 NZ_LR890326:c1513881-1513495 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT238375 WP_000351186.1 NZ_CP093390:788190-788456 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238375 NZ_LR890326:c1513505-1513176 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References