Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 194301..195061 Replicon chromosome
Accession NZ_CP093390
Organism Salmonella enterica strain P289597

Toxin (Protein)


Gene name tacT Uniprot ID A0A2T8TB76
Locus tag MOV19_RS00925 Protein ID WP_000533914.1
Coordinates 194576..195061 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MOV19_RS00920 Protein ID WP_000965886.1
Coordinates 194301..194588 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV19_RS00900 (189706) 189706..190617 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
MOV19_RS00905 (190627) 190627..192696 + 2070 WP_001291749.1 glycine--tRNA ligase subunit beta -
MOV19_RS00910 (193086) 193086..193514 + 429 Protein_182 IS3 family transposase -
MOV19_RS00915 (193656) 193656..194123 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
MOV19_RS00920 (194301) 194301..194588 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MOV19_RS00925 (194576) 194576..195061 + 486 WP_000533914.1 GNAT family N-acetyltransferase Toxin
MOV19_RS00930 (195434) 195434..195973 - 540 WP_000047139.1 copper-binding periplasmic metallochaperone CueP -
MOV19_RS00935 (196150) 196150..196362 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MOV19_RS00940 (196650) 196650..196940 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MOV19_RS00945 (197379) 197379..198089 + 711 WP_080097268.1 DUF3053 domain-containing protein -
MOV19_RS00950 (198139) 198139..199113 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
MOV19_RS00955 (199332) 199332..199994 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.36 Da        Isoelectric Point: 9.5819

>T238373 WP_000533914.1 NZ_CP093390:194576-195061 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTQQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T238373 NZ_LR890326:c1124766-1124224 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT238373 WP_000965886.1 NZ_CP093390:194301-194588 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT238373 NZ_LR890326:c1125061-1124750 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGCCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TB76

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References