Detailed information of TA system TA238372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 24352..24977
• Replicon: plasmid unnamed1
• Accession: NZ_CP093387
• Organism: Salmonella enterica strain P048595

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MOQ57_RS23720
• Protein ID: WP_000911322.1
• Coordinates: 24579..24977 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MOQ57_RS23715
• Protein ID: WP_000450265.1
• Coordinates: 24352..24579 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ57_RS23715 (MOQ57_23715)	24352..24579	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
MOQ57_RS23720 (MOQ57_23720)	24579..24977	+	399	WP_000911322.1	type II toxin-antitoxin system VapC family toxin	Toxin
MOQ57_RS23725 (MOQ57_23725)	24986..27148	-	2163	WP_000009318.1	type IV conjugative transfer system coupling protein TraD	-
MOQ57_RS23730 (MOQ57_23730)	27525..28256	-	732	WP_000782438.1	conjugal transfer complement resistance protein TraT	-
MOQ57_RS23735 (MOQ57_23735)	28292..28786	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	pefB / pefA / pefC / pefD / rck / spvB / spvC / fdeC	1..93849	93849

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14887.13 Da
• Isoelectric Point: 8.5264

>T238372 WP_000911322.1 NZ_CP093387:24579-24977 [Salmonella enterica]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T238372 NZ_LR890326:969668-970036 [Escherichia coli]
ATGAAAACTCTACCTGCAACGACTCCGCAGGCGGCGAAGCCCTGTCTGTCGCCCGTGTCTGTCTGGCAAATGTTACTTAC
TCGTCTACTTGAGCAGCACTATGGCCTAATGTTAAGCGACACACCTTTTAGCGATGAAACAGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTTGTAGAGAAATATGAGTTAGTTCGTATCGATCGCAATGGATTT
ACCTCTCAGGTACAAGCACCATATTTGACTACGACAGACATTCTTCAAGCTAGGAAAGCGTGCGGGCTGATGAGCCGGTG
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGCTGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8509.49 Da
• Isoelectric Point: 4.5358

>AT238372 WP_000450265.1 NZ_CP093387:24352-24579 [Salmonella enterica]
METSVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT238372 NZ_LR890326:969330-969647 [Escherichia coli]
ATGAGTAACATCACATGGGGCCTGCAGCGGGATATCACACCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAACT
GCATTATTTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGACGCCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTTACCACTGGTGAAATGAATCCTCGCCACGCCCACTGCGTCACCCTGTACCAC
GATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGTCGTCTACTCCACTCAACGCTAA