238363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3515967..3516587 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOQ57_RS17360 Protein ID WP_001280991.1
Coordinates 3516369..3516587 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOQ57_RS17355 Protein ID WP_000344807.1
Coordinates 3515967..3516341 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ57_RS17345 (3511106) 3511106..3512299 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOQ57_RS17350 (3512322) 3512322..3515471 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MOQ57_RS17355 (3515967) 3515967..3516341 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOQ57_RS17360 (3516369) 3516369..3516587 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOQ57_RS17365 (3516766) 3516766..3517317 + 552 WP_001278792.1 maltose O-acetyltransferase -
MOQ57_RS17370 (3517434) 3517434..3517904 + 471 WP_000136181.1 YlaC family protein -
MOQ57_RS17375 (3517960) 3517960..3518100 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MOQ57_RS17380 (3518106) 3518106..3518366 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MOQ57_RS17385 (3518591) 3518591..3520141 + 1551 WP_000213139.1 EAL domain-containing protein -
MOQ57_RS17395 (3520372) 3520372..3520761 + 390 WP_000961285.1 MGMT family protein -
MOQ57_RS17400 (3520794) 3520794..3521363 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238363 WP_001280991.1 NZ_CP093386:3516369-3516587 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238363 NZ_LR890323:c4596484-4596200 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCTGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238363 WP_000344807.1 NZ_CP093386:3515967-3516341 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238363 NZ_LR890323:c4596716-4596474 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References