Detailed information of TA system TA238351

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 839276..839936
• Replicon: chromosome
• Accession: NZ_CP093386
• Organism: Salmonella enterica strain P048595

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q57K70
• Locus tag: MOQ57_RS04035
• Protein ID: WP_000244756.1
• Coordinates: 839523..839936 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: MOQ57_RS04030
• Protein ID: WP_000351186.1
• Coordinates: 839276..839542 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ57_RS04010 (835204)	835204..836637	-	1434	WP_001230141.1	6-phospho-beta-glucosidase BglA	-
MOQ57_RS04015 (836796)	836796..837107	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
MOQ57_RS04020 (837271)	837271..837930	+	660	WP_000250289.1	hemolysin III family protein	-
MOQ57_RS04025 (838046)	838046..839026	-	981	WP_000874172.1	tRNA-modifying protein YgfZ	-
MOQ57_RS04030 (839276)	839276..839542	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
MOQ57_RS04035 (839523)	839523..839936	+	414	WP_000244756.1	protein YgfX	Toxin
MOQ57_RS04040 (839989)	839989..840510	-	522	WP_001055885.1	flavodoxin FldB	-
MOQ57_RS04045 (840623)	840623..841519	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
MOQ57_RS04050 (841543)	841543..842256	+	714	WP_000745625.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MOQ57_RS04055 (842262)	842262..843995	+	1734	WP_000813394.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T238351 WP_000244756.1 NZ_CP093386:839523-839936 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T238351 NZ_LR890318:52755-53225 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT238351 WP_000351186.1 NZ_CP093386:839276-839542 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT238351 NZ_LR890318:52315-52758 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAAGTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACTGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A3Z1E9V5

Antitoxin

• AlphaFold DB: A0A5I0YWH4