Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206406..207166 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag MOQ57_RS00965 Protein ID WP_000533909.1
Coordinates 206681..207166 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MOQ57_RS00960 Protein ID WP_000965886.1
Coordinates 206406..206693 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ57_RS00935 (201701) 201701..202003 + 303 WP_000605590.1 YsaB family lipoprotein -
MOQ57_RS00940 (202142) 202142..203053 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
MOQ57_RS00945 (203063) 203063..205132 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
MOQ57_RS00950 (205314) 205314..205589 + 276 Protein_189 IS3 family transposase -
MOQ57_RS00955 (205761) 205761..206228 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
MOQ57_RS00960 (206406) 206406..206693 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MOQ57_RS00965 (206681) 206681..207166 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
MOQ57_RS00970 (207538) 207538..208077 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
MOQ57_RS00975 (208251) 208251..208463 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MOQ57_RS00980 (208752) 208752..209042 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MOQ57_RS00985 (209481) 209481..210191 + 711 WP_000190524.1 DUF3053 domain-containing protein -
MOQ57_RS00990 (210241) 210241..211215 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
MOQ57_RS00995 (211434) 211434..212096 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T238348 WP_000533909.1 NZ_CP093386:206681-207166 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T238348 NZ_LR890317:c4646637-4646353 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT238348 WP_000965886.1 NZ_CP093386:206406-206693 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT238348 NZ_LR890317:c4646869-4646627 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References