Detailed information of TA system TA238345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 442336..442964
• Replicon: chromosome
• Accession: NZ_CP093379
• Organism: Ignatzschineria rhizosphaerae strain HR5S32

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MMG00_RS01955
• Protein ID: WP_242150632.1
• Coordinates: 442785..442964 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MMG00_RS01950
• Protein ID: WP_242150629.1
• Coordinates: 442336..442740 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMG00_RS01920 (MMG00_01920)	438049..438774	+	726	WP_242150618.1	arginine ABC transporter ATP-binding protein ArtP	-
MMG00_RS01925 (MMG00_01925)	438861..439601	+	741	WP_242150621.1	transporter substrate-binding domain-containing protein	-
MMG00_RS01930 (MMG00_01930)	439676..440425	+	750	WP_270049335.1	ABC transporter permease subunit	-
MMG00_RS01935 (MMG00_01935)	440435..441100	+	666	WP_242150624.1	arginine ABC transporter permease ArtM	-
MMG00_RS01945 (MMG00_01945)	441539..441871	-	333	WP_242150627.1	hypothetical protein	-
MMG00_RS01950 (MMG00_01950)	442336..442740	-	405	WP_242150629.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MMG00_RS01955 (MMG00_01955)	442785..442964	-	180	WP_242150632.1	type II toxin-antitoxin system HicA family toxin	Toxin
MMG00_RS01960 (MMG00_01960)	443204..443437	+	234	WP_242150635.1	EexN family lipoprotein	-
MMG00_RS01965 (MMG00_01965)	443562..444437	+	876	WP_242150638.1	hypothetical protein	-
MMG00_RS01970 (MMG00_01970)	444636..445259	+	624	WP_242150641.1	hypothetical protein	-
MMG00_RS01975 (MMG00_01975)	445384..446496	+	1113	WP_242150644.1	XRE family transcriptional regulator	-
MMG00_RS01980 (MMG00_01980)	446635..446934	+	300	WP_242150647.1	hypothetical protein	-
MMG00_RS01985 (MMG00_01985)	447408..447953	+	546	WP_242150650.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6693.90 Da
• Isoelectric Point: 10.9862

>T238345 WP_242150632.1 NZ_CP093379:c442964-442785 [Ignatzschineria rhizosphaerae]
MNSKDLIKMIEKDGWYLVATRGSHHQFKHPTKSGRVTIPHPKKDLPKGTVKNIMKQAGI

Nucleotide

• Length: 180 bp

>T238345 NZ_LR890317:3915354-3915572 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15253.01 Da
• Isoelectric Point: 4.4882

>AT238345 WP_242150629.1 NZ_CP093379:c442740-442336 [Ignatzschineria rhizosphaerae]
MLFHLVIHKDEDSTYGVTIPSLEGAFSHGDTLEEAVLNSKEAIQFHLEGILEDGIEPDFKHLTLDEIKTNPDYQGADLIS
VDIDTSAYTLKPERFNVSWPRYLIKEVDQYTTQHPDTRSSFLAKAAKKYIEQNP

Nucleotide

• Length: 405 bp

>AT238345 NZ_LR890317:3914953-3915327 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG