Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2691133..2691752 Replicon chromosome
Accession NZ_CP093376
Organism Cronobacter sakazakii strain 70402496

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S9UIC9
Locus tag MOQ97_RS13115 Protein ID WP_004386909.1
Coordinates 2691534..2691752 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag MOQ97_RS13110 Protein ID WP_004386908.1
Coordinates 2691133..2691507 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ97_RS13100 (MOQ97_13095) 2686294..2687499 + 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOQ97_RS13105 (MOQ97_13100) 2687521..2690670 + 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit AcrB -
MOQ97_RS13110 (MOQ97_13105) 2691133..2691507 + 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
MOQ97_RS13115 (MOQ97_13110) 2691534..2691752 + 219 WP_004386909.1 HHA domain-containing protein Toxin
MOQ97_RS13120 (MOQ97_13115) 2691961..2692512 + 552 WP_004386910.1 maltose O-acetyltransferase -
MOQ97_RS13125 (MOQ97_13120) 2692632..2693141 + 510 WP_007891920.1 YlaC family protein -
MOQ97_RS13130 (MOQ97_13125) 2693170..2693310 - 141 WP_004386911.1 type B 50S ribosomal protein L36 -
MOQ97_RS13135 (MOQ97_13130) 2693314..2693574 - 261 WP_004386912.1 type B 50S ribosomal protein L31 -
MOQ97_RS13140 (MOQ97_13135) 2693715..2695616 - 1902 WP_014729414.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8598.02 Da        Isoelectric Point: 9.4828

>T238344 WP_004386909.1 NZ_CP093376:2691534-2691752 [Cronobacter sakazakii]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T238344 NZ_LR890317:c3103255-3103079 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT238344 WP_004386908.1 NZ_CP093376:2691133-2691507 [Cronobacter sakazakii]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp

>AT238344 NZ_LR890317:c3103031-3102624 [Klebsiella pneumoniae]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTAACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCTTGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGTACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UIC9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References