Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 379554..380217 Replicon chromosome
Accession NZ_CP093376
Organism Cronobacter sakazakii strain 70402496

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag MOQ97_RS02345 Protein ID WP_004385675.1
Coordinates 379801..380217 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag MOQ97_RS02340 Protein ID WP_004385674.1
Coordinates 379554..379820 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ97_RS02315 (MOQ97_02315) 374582..376015 - 1434 WP_004385669.1 6-phospho-beta-glucosidase -
MOQ97_RS02320 (MOQ97_02320) 376167..376895 - 729 WP_004385670.1 MurR/RpiR family transcriptional regulator -
MOQ97_RS02325 (MOQ97_02325) 377072..377386 + 315 WP_004385671.1 N(4)-acetylcytidine aminohydrolase -
MOQ97_RS02330 (MOQ97_02330) 377529..378182 + 654 WP_004385672.1 hemolysin III family protein -
MOQ97_RS02335 (MOQ97_02335) 378287..379276 - 990 WP_004385673.1 tRNA-modifying protein YgfZ -
MOQ97_RS02340 (MOQ97_02340) 379554..379820 + 267 WP_004385674.1 FAD assembly factor SdhE Antitoxin
MOQ97_RS02345 (MOQ97_02345) 379801..380217 + 417 WP_004385675.1 protein YgfX Toxin
MOQ97_RS02350 (MOQ97_02350) 380231..380752 - 522 WP_004385676.1 flavodoxin FldB -
MOQ97_RS02355 (MOQ97_02355) 380854..381750 + 897 WP_004385677.1 site-specific tyrosine recombinase XerD -
MOQ97_RS02360 (MOQ97_02360) 381773..382492 + 720 WP_080781176.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOQ97_RS02365 (MOQ97_02365) 382496..384229 + 1734 WP_004385679.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16446.46 Da        Isoelectric Point: 11.4887

>T238332 WP_004385675.1 NZ_CP093376:379801-380217 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYQLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPIGDKR

Download         Length: 417 bp

>T238332 NZ_LR890312:c1307168-1306839 [Klebsiella oxytoca]
ATGCAAAAAATATCATCACACCCGACACGGGCGAATCAGCCCTGCCTGTCACCCATTGAAATCTGGCAGCGACTCCTGAC
TTATCTGTTATCGCAGCACTACGGCCTGACGCTGAATGACACACCGTTCAGTAATGAAACCATTATTCATGAGCACATTG
ATGCCGGTATCACTCTGGCTGACGCTATGAATTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10358.84 Da        Isoelectric Point: 4.6289

>AT238332 WP_004385674.1 NZ_CP093376:379554-379820 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKCVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT238332 NZ_LR890312:c1307572-1307207 [Klebsiella oxytoca]
ATGAACAATCATTCAGAATCCGGTACCAAGCCGGAGTGTCCCGCCTGCCAGCTGTGGGGACTCAAACGTGCTATTACCCC
CTATTTTGGGGCTCGTCTGGTACAGGAAGGCAACCGGGTGCATTTTCTCGCTGACCGCGCCGGATTCAACGGTGCTTTCA
GTGACGGGGATGTATTACACCTGGACCAAGCTTTTCCCCTGATACTCAAGCAACTGGAACTAATGCTCACCAGCGGCGAG
CTCAATCCCCGCTATCAGCACTGTGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTTCTATCTATCCTGAGCAGACTGAGCCACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References