238330

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 19746..20416 Replicon chromosome
Accession NZ_CP093376
Organism Cronobacter sakazakii strain 70402496

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag MOQ97_RS00615 Protein ID WP_007852532.1
Coordinates 19746..20096 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag MOQ97_RS00620 Protein ID WP_015386308.1
Coordinates 20093..20416 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ97_RS00600 (MOQ97_00600) 17296..18927 + 1632 WP_007852537.1 Na/Pi cotransporter family protein -
MOQ97_RS00605 (MOQ97_00605) 18944..19219 - 276 WP_007852536.1 putative addiction module antidote protein -
MOQ97_RS00610 (MOQ97_00610) 19224..19529 - 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin -
MOQ97_RS00615 (MOQ97_00615) 19746..20096 + 351 WP_007852532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOQ97_RS00620 (MOQ97_00620) 20093..20416 + 324 WP_015386308.1 helix-turn-helix transcriptional regulator Antitoxin
MOQ97_RS00625 (MOQ97_00625) 20443..20715 - 273 WP_004387517.1 DUF3811 domain-containing protein -
MOQ97_RS00630 (MOQ97_00630) 20806..21741 - 936 WP_004387518.1 ketopantoate/pantoate/pantothenate transporter PanS -
MOQ97_RS00635 (MOQ97_00635) 21903..23495 - 1593 WP_004387519.1 RNA repair transcriptional activator RtcR -
MOQ97_RS00640 (MOQ97_00640) 23971..25104 + 1134 WP_004387521.1 slipin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.99 Da        Isoelectric Point: 10.2932

>T238330 WP_007852532.1 NZ_CP093376:19746-20096 [Cronobacter sakazakii]
MIKPLFWVGQARKDLQALPEDVQDLFGYALYLAQQGRRHPQARPLKGFGGAGVLEVVEDYQGNAFRAVYTVRLGEAIYVL
HVFQKKSSSGIATPRPEMEKIEQRLKAAQRHAGGLK

Download         Length: 351 bp

>T238330 NZ_LR890308:49658-49969 [Klebsiella pneumoniae]
ATGCACATTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11804.88 Da        Isoelectric Point: 6.9798

>AT238330 WP_015386308.1 NZ_CP093376:20093-20416 [Cronobacter sakazakii]
MTADIERSNGNVYDDLGLIDAEEMELKAQLAMAISDILKARGLTQQEAARLLGMTQPKLSLLLRGQFRGISETKMMACLM
LLGRDISIVVGEAQHARGKMRLIYQPA

Download         Length: 324 bp

>AT238330 NZ_LR890308:49966-50385 [Klebsiella pneumoniae]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References