Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 263390..264033 Replicon plasmid p423_13
Accession NZ_CP093374
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag MNU28_RS24235 Protein ID WP_001044768.1
Coordinates 263617..264033 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag MNU28_RS24230 Protein ID WP_001261287.1
Coordinates 263390..263620 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS24215 (259501) 259501..260589 + 1089 WP_000952231.1 hypothetical protein -
MNU28_RS24220 (260591) 260591..261460 + 870 WP_000253407.1 hypothetical protein -
MNU28_RS24225 (261517) 261517..263082 - 1566 WP_000741348.1 AAA family ATPase -
MNU28_RS24230 (263390) 263390..263620 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MNU28_RS24235 (263617) 263617..264033 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
MNU28_RS24240 (264195) 264195..266333 - 2139 WP_000350635.1 AAA family ATPase -
MNU28_RS24245 (266687) 266687..266944 + 258 WP_000343085.1 hypothetical protein -
MNU28_RS24250 (266944) 266944..267534 + 591 WP_247247528.1 hypothetical protein -
MNU28_RS24255 (267800) 267800..268246 + 447 WP_247247530.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / qacE / sul1 / tet(A) / blaCTX-M-65 / fosA3 / floR / aph(4)-Ia / aac(3)-IVa / dfrA14 faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..320713 320713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T238327 WP_001044768.1 NZ_CP093374:263617-264033 [Salmonella enterica subsp. enterica serovar Infantis]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T238327 NZ_LR890307:c4665186-4664902 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT238327 WP_001261287.1 NZ_CP093374:263390-263620 [Salmonella enterica subsp. enterica serovar Infantis]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT238327 NZ_LR890307:c4665418-4665176 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References