Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 49599..50124 | Replicon | plasmid p423_13 |
| Accession | NZ_CP093374 | ||
| Organism | Salmonella enterica subsp. enterica serovar Infantis strain 423_13 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A5Y5FBU7 |
| Locus tag | MNU28_RS23220 | Protein ID | WP_023994134.1 |
| Coordinates | 49819..50124 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A5T8X4Y4 |
| Locus tag | MNU28_RS23215 | Protein ID | WP_023994135.1 |
| Coordinates | 49599..49817 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU28_RS23170 (44654) | 44654..44983 | + | 330 | WP_247247541.1 | hypothetical protein | - |
| MNU28_RS23175 (44959) | 44959..45074 | + | 116 | Protein_49 | hypothetical protein | - |
| MNU28_RS23180 (45043) | 45043..45396 | + | 354 | WP_247247542.1 | hypothetical protein | - |
| MNU28_RS23185 (45599) | 45599..46189 | + | 591 | WP_023994140.1 | hypothetical protein | - |
| MNU28_RS23190 (46255) | 46255..46467 | + | 213 | WP_023994139.1 | FaeA/PapI family transcriptional regulator | - |
| MNU28_RS23195 (46728) | 46728..46889 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| MNU28_RS23200 (46915) | 46915..47763 | + | 849 | WP_023994138.1 | SdiA-regulated domain-containing protein | - |
| MNU28_RS23205 (48333) | 48333..48749 | - | 417 | WP_023994137.1 | type II toxin-antitoxin system VapC family toxin | - |
| MNU28_RS23210 (48746) | 48746..48976 | - | 231 | WP_023994136.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MNU28_RS23215 (49599) | 49599..49817 | + | 219 | WP_023994135.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| MNU28_RS23220 (49819) | 49819..50124 | + | 306 | WP_023994134.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| MNU28_RS23225 (50126) | 50126..50416 | + | 291 | WP_023994133.1 | hypothetical protein | - |
| MNU28_RS24575 (50413) | 50413..50688 | + | 276 | Protein_60 | 3'-5' exonuclease | - |
| MNU28_RS23240 (50759) | 50759..50875 | + | 117 | Protein_61 | hypothetical protein | - |
| MNU28_RS23245 (50865) | 50865..51580 | - | 716 | Protein_62 | transposase | - |
| MNU28_RS23250 (52862) | 52862..53398 | + | 537 | WP_023994130.1 | fimbrial protein | - |
| MNU28_RS23255 (53457) | 53457..54178 | + | 722 | Protein_64 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | ant(3'')-Ia / qacE / sul1 / tet(A) / blaCTX-M-65 / fosA3 / floR / aph(4)-Ia / aac(3)-IVa / dfrA14 | faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..320713 | 320713 | |
| - | flank | IS/Tn | - | - | 51227..51526 | 299 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11708.47 Da Isoelectric Point: 6.4685
>T238322 WP_023994134.1 NZ_CP093374:49819-50124 [Salmonella enterica subsp. enterica serovar Infantis]
MQFKVYTYKRESRYRLFVDVQSDIVDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASFIGEEV
AELSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIVDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASFIGEEV
AELSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T238322 NZ_LR890307:786501-786911 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8261.18 Da Isoelectric Point: 4.7405
>AT238322 WP_023994135.1 NZ_CP093374:49599-49817 [Salmonella enterica subsp. enterica serovar Infantis]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQKEARRLRAERWQAENQEGMAEVARFIEANGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQKEARRLRAERWQAENQEGMAEVARFIEANGSFADENRDW
Download Length: 219 bp
>AT238322 NZ_LR890307:786254-786520 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y5FBU7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T8X4Y4 |