Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 28607..29364 Replicon plasmid p423_13
Accession NZ_CP093374
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name tacT Uniprot ID A0A241PXX4
Locus tag MNU28_RS23080 Protein ID WP_023994162.1
Coordinates 28882..29364 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A727Z1I8
Locus tag MNU28_RS23075 Protein ID WP_001195098.1
Coordinates 28607..28891 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS23030 (24448) 24448..24594 - 147 Protein_20 IS66 family insertion sequence element accessory protein TnpB -
MNU28_RS23035 (24581) 24581..24910 - 330 WP_023994169.1 hypothetical protein -
MNU28_RS23040 (25034) 25034..25887 + 854 Protein_22 site-specific tyrosine recombinase XerC -
MNU28_RS23045 (25856) 25856..26143 + 288 WP_031619580.1 damage-inducible protein J -
MNU28_RS23050 (26140) 26140..26445 + 306 WP_023994167.1 type II toxin-antitoxin system RelE/ParE family toxin -
MNU28_RS23055 (27195) 27195..27458 + 264 WP_023994165.1 DUF977 family protein -
MNU28_RS23060 (27484) 27484..27819 + 336 WP_023994164.1 hypothetical protein -
MNU28_RS23065 (28041) 28041..28238 - 198 Protein_27 PIN domain-containing protein -
MNU28_RS23070 (28362) 28362..28451 + 90 WP_071790431.1 helix-turn-helix domain-containing protein -
MNU28_RS23075 (28607) 28607..28891 + 285 WP_001195098.1 DUF1778 domain-containing protein Antitoxin
MNU28_RS23080 (28882) 28882..29364 + 483 WP_023994162.1 GNAT family N-acetyltransferase Toxin
MNU28_RS23085 (29679) 29679..30104 + 426 Protein_31 transposase -
MNU28_RS23090 (30420) 30420..30629 + 210 WP_023994160.1 hemolysin expression modulator Hha -
MNU28_RS23095 (30703) 30703..31055 - 353 Protein_33 transposase -
MNU28_RS23100 (31282) 31282..32255 + 974 Protein_34 IS256 family transposase -
MNU28_RS23105 (32257) 32257..32499 + 243 WP_023994156.1 hypothetical protein -
MNU28_RS23110 (32570) 32570..33529 + 960 WP_088884186.1 Rpn family recombination-promoting nuclease/putative transposase -
MNU28_RS23115 (33571) 33571..33822 - 252 WP_023994153.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / qacE / sul1 / tet(A) / blaCTX-M-65 / fosA3 / floR / aph(4)-Ia / aac(3)-IVa / dfrA14 faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..320713 320713
- inside IScluster/Tn - - 23152..35386 12234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-149)

Antitoxin

Vibrio phage ICP1, Orf50

(13-88)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17971.54 Da        Isoelectric Point: 6.8521

>T238320 WP_023994162.1 NZ_CP093374:28882-29364 [Salmonella enterica subsp. enterica serovar Infantis]
MEISVTAPELLNEEHYLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPEGTKRVVGYYSIATGSVSHASLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPIAPNTLFYKI

Download         Length: 483 bp

>T238320 NZ_LR890307:329008-329376 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10964.52 Da        Isoelectric Point: 9.6539

>AT238320 WP_001195098.1 NZ_CP093374:28607-28891 [Salmonella enterica subsp. enterica serovar Infantis]
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK

Download         Length: 285 bp

>AT238320 NZ_LR890307:328790-329011 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXX4

Antitoxin

Source ID Structure
AlphaFold DB A0A727Z1I8

References