Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/DUF1778(antitoxin) |
| Location | 28607..29364 | Replicon | plasmid p423_13 |
| Accession | NZ_CP093374 | ||
| Organism | Salmonella enterica subsp. enterica serovar Infantis strain 423_13 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A241PXX4 |
| Locus tag | MNU28_RS23080 | Protein ID | WP_023994162.1 |
| Coordinates | 28882..29364 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A727Z1I8 |
| Locus tag | MNU28_RS23075 | Protein ID | WP_001195098.1 |
| Coordinates | 28607..28891 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU28_RS23030 (24448) | 24448..24594 | - | 147 | Protein_20 | IS66 family insertion sequence element accessory protein TnpB | - |
| MNU28_RS23035 (24581) | 24581..24910 | - | 330 | WP_023994169.1 | hypothetical protein | - |
| MNU28_RS23040 (25034) | 25034..25887 | + | 854 | Protein_22 | site-specific tyrosine recombinase XerC | - |
| MNU28_RS23045 (25856) | 25856..26143 | + | 288 | WP_031619580.1 | damage-inducible protein J | - |
| MNU28_RS23050 (26140) | 26140..26445 | + | 306 | WP_023994167.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MNU28_RS23055 (27195) | 27195..27458 | + | 264 | WP_023994165.1 | DUF977 family protein | - |
| MNU28_RS23060 (27484) | 27484..27819 | + | 336 | WP_023994164.1 | hypothetical protein | - |
| MNU28_RS23065 (28041) | 28041..28238 | - | 198 | Protein_27 | PIN domain-containing protein | - |
| MNU28_RS23070 (28362) | 28362..28451 | + | 90 | WP_071790431.1 | helix-turn-helix domain-containing protein | - |
| MNU28_RS23075 (28607) | 28607..28891 | + | 285 | WP_001195098.1 | DUF1778 domain-containing protein | Antitoxin |
| MNU28_RS23080 (28882) | 28882..29364 | + | 483 | WP_023994162.1 | GNAT family N-acetyltransferase | Toxin |
| MNU28_RS23085 (29679) | 29679..30104 | + | 426 | Protein_31 | transposase | - |
| MNU28_RS23090 (30420) | 30420..30629 | + | 210 | WP_023994160.1 | hemolysin expression modulator Hha | - |
| MNU28_RS23095 (30703) | 30703..31055 | - | 353 | Protein_33 | transposase | - |
| MNU28_RS23100 (31282) | 31282..32255 | + | 974 | Protein_34 | IS256 family transposase | - |
| MNU28_RS23105 (32257) | 32257..32499 | + | 243 | WP_023994156.1 | hypothetical protein | - |
| MNU28_RS23110 (32570) | 32570..33529 | + | 960 | WP_088884186.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| MNU28_RS23115 (33571) | 33571..33822 | - | 252 | WP_023994153.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | ant(3'')-Ia / qacE / sul1 / tet(A) / blaCTX-M-65 / fosA3 / floR / aph(4)-Ia / aac(3)-IVa / dfrA14 | faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..320713 | 320713 | |
| - | inside | IScluster/Tn | - | - | 23152..35386 | 12234 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17971.54 Da Isoelectric Point: 6.8521
>T238320 WP_023994162.1 NZ_CP093374:28882-29364 [Salmonella enterica subsp. enterica serovar Infantis]
MEISVTAPELLNEEHYLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPEGTKRVVGYYSIATGSVSHASLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPIAPNTLFYKI
MEISVTAPELLNEEHYLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPEGTKRVVGYYSIATGSVSHASLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPIAPNTLFYKI
Download Length: 483 bp
>T238320 NZ_LR890307:329008-329376 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10964.52 Da Isoelectric Point: 9.6539
>AT238320 WP_001195098.1 NZ_CP093374:28607-28891 [Salmonella enterica subsp. enterica serovar Infantis]
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK
Download Length: 285 bp
>AT238320 NZ_LR890307:328790-329011 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A241PXX4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A727Z1I8 |