Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 14527..15117 Replicon plasmid p423_13
Accession NZ_CP093374
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag MNU28_RS22995 Protein ID WP_023994178.1
Coordinates 14785..15117 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag MNU28_RS22990 Protein ID WP_023994179.1
Coordinates 14527..14784 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS22965 (9550) 9550..9993 + 444 WP_088364536.1 hypothetical protein -
MNU28_RS22970 (10026) 10026..11051 + 1026 WP_023994180.1 IS630 family transposase -
MNU28_RS22975 (11055) 11055..12074 - 1020 WP_223155817.1 hypothetical protein -
MNU28_RS22980 (12214) 12214..12720 - 507 WP_223155815.1 hypothetical protein -
MNU28_RS22985 (12831) 12831..13916 - 1086 WP_223155813.1 hypothetical protein -
MNU28_RS22990 (14527) 14527..14784 + 258 WP_023994179.1 hypothetical protein Antitoxin
MNU28_RS22995 (14785) 14785..15117 + 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MNU28_RS23000 (15717) 15717..16322 + 606 Protein_14 IS481 family transposase -
MNU28_RS23005 (16621) 16621..18843 - 2223 WP_023994175.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / qacE / sul1 / tet(A) / blaCTX-M-65 / fosA3 / floR / aph(4)-Ia / aac(3)-IVa / dfrA14 faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..320713 320713
- inside IScluster/Tn - - 10014..16322 6308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11787.54 Da        Isoelectric Point: 9.3417

>T238319 WP_023994178.1 NZ_CP093374:14785-15117 [Salmonella enterica subsp. enterica serovar Infantis]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

>T238319 NZ_LR890303:c11151-10900 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATCACATTGTATGATGCCGTGCTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9374.86 Da        Isoelectric Point: 4.4354

>AT238319 WP_023994179.1 NZ_CP093374:14527-14784 [Salmonella enterica subsp. enterica serovar Infantis]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL

Download         Length: 258 bp

>AT238319 NZ_LR890303:c10913-10686 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References