Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 14527..15117 | Replicon | plasmid p423_13 |
Accession | NZ_CP093374 | ||
Organism | Salmonella enterica subsp. enterica serovar Infantis strain 423_13 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A241PXU0 |
Locus tag | MNU28_RS22995 | Protein ID | WP_023994178.1 |
Coordinates | 14785..15117 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | A0A5T3Q5H6 |
Locus tag | MNU28_RS22990 | Protein ID | WP_023994179.1 |
Coordinates | 14527..14784 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MNU28_RS22965 (9550) | 9550..9993 | + | 444 | WP_088364536.1 | hypothetical protein | - |
MNU28_RS22970 (10026) | 10026..11051 | + | 1026 | WP_023994180.1 | IS630 family transposase | - |
MNU28_RS22975 (11055) | 11055..12074 | - | 1020 | WP_223155817.1 | hypothetical protein | - |
MNU28_RS22980 (12214) | 12214..12720 | - | 507 | WP_223155815.1 | hypothetical protein | - |
MNU28_RS22985 (12831) | 12831..13916 | - | 1086 | WP_223155813.1 | hypothetical protein | - |
MNU28_RS22990 (14527) | 14527..14784 | + | 258 | WP_023994179.1 | hypothetical protein | Antitoxin |
MNU28_RS22995 (14785) | 14785..15117 | + | 333 | WP_023994178.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MNU28_RS23000 (15717) | 15717..16322 | + | 606 | Protein_14 | IS481 family transposase | - |
MNU28_RS23005 (16621) | 16621..18843 | - | 2223 | WP_023994175.1 | DEAD/DEAH box helicase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | ant(3'')-Ia / qacE / sul1 / tet(A) / blaCTX-M-65 / fosA3 / floR / aph(4)-Ia / aac(3)-IVa / dfrA14 | faeC / faeD / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtE / ybtT / ybtU / irp1 / irp2 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..320713 | 320713 | |
- | inside | IScluster/Tn | - | - | 10014..16322 | 6308 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11787.54 Da Isoelectric Point: 9.3417
>T238319 WP_023994178.1 NZ_CP093374:14785-15117 [Salmonella enterica subsp. enterica serovar Infantis]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS
Download Length: 333 bp
>T238319 NZ_LR890303:c11151-10900 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATCACATTGTATGATGCCGTGCTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATCACATTGTATGATGCCGTGCTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9374.86 Da Isoelectric Point: 4.4354
>AT238319 WP_023994179.1 NZ_CP093374:14527-14784 [Salmonella enterica subsp. enterica serovar Infantis]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL
Download Length: 258 bp
>AT238319 NZ_LR890303:c10913-10686 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A241PXU0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5T3Q5H6 |