238316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4294380..4295140 Replicon chromosome
Accession NZ_CP093373
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag MNU28_RS20855 Protein ID WP_000533909.1
Coordinates 4294380..4294865 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MNU28_RS20860 Protein ID WP_000965886.1
Coordinates 4294853..4295140 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS20825 (4289451) 4289451..4290113 + 663 WP_000747548.1 OmpA family lipoprotein -
MNU28_RS20830 (4290332) 4290332..4291306 + 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
MNU28_RS20835 (4291356) 4291356..4292066 - 711 WP_000190524.1 DUF3053 domain-containing protein -
MNU28_RS20840 (4292505) 4292505..4292795 + 291 WP_000455790.1 HTH-type transcriptional regulator -
MNU28_RS20845 (4293083) 4293083..4293295 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MNU28_RS20850 (4293469) 4293469..4294008 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
MNU28_RS20855 (4294380) 4294380..4294865 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
MNU28_RS20860 (4294853) 4294853..4295140 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MNU28_RS20865 (4295306) 4295306..4295864 - 559 Protein_4080 cysteine hydrolase -
MNU28_RS20870 (4295953) 4295953..4297155 - 1203 WP_023201740.1 MFS transporter -
MNU28_RS20875 (4297240) 4297240..4297890 + 651 WP_023993641.1 GntR family transcriptional regulator -
MNU28_RS20880 (4298009) 4298009..4298437 - 429 Protein_4083 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T238316 WP_000533909.1 NZ_CP093373:c4294865-4294380 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T238316 NZ_LR890301:28345-28503 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT238316 WP_000965886.1 NZ_CP093373:c4295140-4294853 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT238316 NZ_LR890301:28234-28299 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References