Detailed information of TA system TA238315

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4182494..4183080
• Replicon: chromosome
• Accession: NZ_CP093373
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A5Y4K907
• Locus tag: MNU28_RS20355
• Protein ID: WP_023202025.1
• Coordinates: 4182494..4182862 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: MNU28_RS20360
• Protein ID: WP_023993856.1
• Coordinates: 4182859..4183080 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU28_RS20335 (4178013)	4178013..4179083	-	1071	WP_000907846.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
MNU28_RS20340 (4179085)	4179085..4179930	-	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
MNU28_RS20345 (4179927)	4179927..4180814	-	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
MNU28_RS20350 (4180919)	4180919..4182235	-	1317	WP_023993857.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
MNU28_RS20355 (4182494)	4182494..4182862	-	369	WP_023202025.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
MNU28_RS20360 (4182859)	4182859..4183080	-	222	WP_023993856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MNU28_RS20365 (4183211)	4183211..4183924	-	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
MNU28_RS20370 (4183926)	4183926..4184693	-	768	WP_000082083.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
MNU28_RS20375 (4184690)	4184690..4185967	-	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
MNU28_RS20380 (4185964)	4185964..4186890	-	927	WP_023183687.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
MNU28_RS20385 (4186950)	4186950..4188059	-	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4177276..4185967	8691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13703.01 Da
• Isoelectric Point: 6.7252

>T238315 WP_023202025.1 NZ_CP093373:c4182862-4182494 [Salmonella enterica subsp. enterica serovar Infantis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRWHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T238315 NZ_LR890300:151796-152176 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8152.14 Da
• Isoelectric Point: 5.0637

>AT238315 WP_023993856.1 NZ_CP093373:c4183080-4182859 [Salmonella enterica subsp. enterica serovar Infantis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRDLADK

Nucleotide

• Length: 222 bp

>AT238315 NZ_LR890300:151575-151796 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: A0A5Y4K907