Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3653045..3653705 Replicon chromosome
Accession NZ_CP093373
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag MNU28_RS17760 Protein ID WP_000244761.1
Coordinates 3653045..3653458 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MNU28_RS17765 Protein ID WP_000351186.1
Coordinates 3653439..3653705 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS17740 (3648986) 3648986..3650719 - 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -
MNU28_RS17745 (3650725) 3650725..3651438 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MNU28_RS17750 (3651462) 3651462..3652358 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MNU28_RS17755 (3652471) 3652471..3652992 + 522 WP_001055885.1 flavodoxin FldB -
MNU28_RS17760 (3653045) 3653045..3653458 - 414 WP_000244761.1 protein YgfX Toxin
MNU28_RS17765 (3653439) 3653439..3653705 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MNU28_RS17770 (3653955) 3653955..3654935 + 981 WP_023260866.1 tRNA-modifying protein YgfZ -
MNU28_RS17775 (3655051) 3655051..3655710 - 660 WP_000250289.1 hemolysin III family protein -
MNU28_RS17780 (3655874) 3655874..3656185 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MNU28_RS17785 (3656343) 3656343..3657776 + 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T238314 WP_000244761.1 NZ_CP093373:c3653458-3653045 [Salmonella enterica subsp. enterica serovar Infantis]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T238314 NZ_LR890300:c142208-141903 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT238314 WP_000351186.1 NZ_CP093373:c3653705-3653439 [Salmonella enterica subsp. enterica serovar Infantis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238314 NZ_LR890300:c142428-142210 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References