Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 3485802..3486616 | Replicon | chromosome |
Accession | NZ_CP093373 | ||
Organism | Salmonella enterica subsp. enterica serovar Infantis strain 423_13 |
Toxin (Protein)
Gene name | TacT3 | Uniprot ID | A0A5T8FHB0 |
Locus tag | MNU28_RS16990 | Protein ID | WP_023994249.1 |
Coordinates | 3486089..3486616 (+) | Length | 176 a.a. |
Antitoxin (Protein)
Gene name | TacA3 | Uniprot ID | M7S6I2 |
Locus tag | MNU28_RS16985 | Protein ID | WP_000855694.1 |
Coordinates | 3485802..3486092 (+) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MNU28_RS16955 (3481752) | 3481752..3482402 | - | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
MNU28_RS16960 (3482858) | 3482858..3483301 | + | 444 | WP_023993678.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
MNU28_RS16965 (3483733) | 3483733..3484182 | + | 450 | WP_000381612.1 | membrane protein | - |
MNU28_RS16970 (3484167) | 3484167..3484514 | + | 348 | WP_001669174.1 | DUF1493 family protein | - |
MNU28_RS16975 (3484787) | 3484787..3485113 | - | 327 | WP_000393300.1 | hypothetical protein | - |
MNU28_RS16980 (3485354) | 3485354..3485532 | + | 179 | Protein_3320 | IS3 family transposase | - |
MNU28_RS16985 (3485802) | 3485802..3486092 | + | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
MNU28_RS16990 (3486089) | 3486089..3486616 | + | 528 | WP_023994249.1 | GNAT family N-acetyltransferase | Toxin |
MNU28_RS16995 (3486689) | 3486689..3486906 | - | 218 | Protein_3323 | IS5/IS1182 family transposase | - |
MNU28_RS17000 (3487241) | 3487241..3487897 | + | 657 | WP_000420451.1 | protein-serine/threonine phosphatase | - |
MNU28_RS17005 (3488068) | 3488068..3488589 | - | 522 | WP_023994250.1 | hypothetical protein | - |
MNU28_RS17010 (3488748) | 3488748..3491315 | + | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 3486689..3486829 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19025.89 Da Isoelectric Point: 9.6423
>T238313 WP_023994249.1 NZ_CP093373:3486089-3486616 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T238313 NZ_LR890300:c122477-122319 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT238313 WP_000855694.1 NZ_CP093373:3485802-3486092 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT238313 NZ_LR890300:c122745-122521 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5T8FHB0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V8SJE7 |