Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3485802..3486616 Replicon chromosome
Accession NZ_CP093373
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag MNU28_RS16990 Protein ID WP_023994249.1
Coordinates 3486089..3486616 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MNU28_RS16985 Protein ID WP_000855694.1
Coordinates 3485802..3486092 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS16955 (3481752) 3481752..3482402 - 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
MNU28_RS16960 (3482858) 3482858..3483301 + 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MNU28_RS16965 (3483733) 3483733..3484182 + 450 WP_000381612.1 membrane protein -
MNU28_RS16970 (3484167) 3484167..3484514 + 348 WP_001669174.1 DUF1493 family protein -
MNU28_RS16975 (3484787) 3484787..3485113 - 327 WP_000393300.1 hypothetical protein -
MNU28_RS16980 (3485354) 3485354..3485532 + 179 Protein_3320 IS3 family transposase -
MNU28_RS16985 (3485802) 3485802..3486092 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MNU28_RS16990 (3486089) 3486089..3486616 + 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
MNU28_RS16995 (3486689) 3486689..3486906 - 218 Protein_3323 IS5/IS1182 family transposase -
MNU28_RS17000 (3487241) 3487241..3487897 + 657 WP_000420451.1 protein-serine/threonine phosphatase -
MNU28_RS17005 (3488068) 3488068..3488589 - 522 WP_023994250.1 hypothetical protein -
MNU28_RS17010 (3488748) 3488748..3491315 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3486689..3486829 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T238313 WP_023994249.1 NZ_CP093373:3486089-3486616 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T238313 NZ_LR890300:c122477-122319 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT238313 WP_000855694.1 NZ_CP093373:3485802-3486092 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT238313 NZ_LR890300:c122745-122521 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References