Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2327243..2327765 Replicon chromosome
Accession NZ_CP093373
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MNU28_RS11330 Protein ID WP_000221343.1
Coordinates 2327481..2327765 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag MNU28_RS11325 Protein ID WP_000885426.1
Coordinates 2327243..2327491 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS11295 (2322663) 2322663..2323643 - 981 WP_023993266.1 nitronate monooxygenase -
MNU28_RS11300 (2323817) 2323817..2324725 - 909 WP_023994284.1 LysR family transcriptional regulator -
MNU28_RS11305 (2325631) 2325631..2326077 + 447 Protein_2205 helix-turn-helix domain-containing protein -
MNU28_RS11310 (2326076) 2326076..2326270 - 195 Protein_2206 hypothetical protein -
MNU28_RS11315 (2326550) 2326550..2326886 - 337 Protein_2207 DUF1493 family protein -
MNU28_RS11320 (2326876) 2326876..2327091 - 216 WP_023993263.1 phage protein -
MNU28_RS11325 (2327243) 2327243..2327491 + 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MNU28_RS11330 (2327481) 2327481..2327765 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNU28_RS11335 (2327936) 2327936..2328325 + 390 WP_023993262.1 RidA family protein -
MNU28_RS11340 (2328373) 2328373..2329452 - 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MNU28_RS11345 (2329645) 2329645..2330133 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
MNU28_RS11350 (2330178) 2330178..2331686 + 1509 WP_023993260.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2320934..2334543 13609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T238312 WP_000221343.1 NZ_CP093373:2327481-2327765 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T238312 NZ_LR890300:c83174-83040 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT238312 WP_000885426.1 NZ_CP093373:2327243-2327491 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT238312 NZ_LR890300:83219-83279 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References