Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1109460..1110080 Replicon chromosome
Accession NZ_CP093373
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MNU28_RS05210 Protein ID WP_001280991.1
Coordinates 1109460..1109678 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MNU28_RS05215 Protein ID WP_000344807.1
Coordinates 1109706..1110080 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS05165 (1104685) 1104685..1105254 + 570 WP_000779802.1 YbaY family lipoprotein -
MNU28_RS05170 (1105287) 1105287..1105676 - 390 WP_000961285.1 MGMT family protein -
MNU28_RS24560 (1105907) 1105907..1107456 - 1550 Protein_1006 EAL domain-containing protein -
MNU28_RS05190 (1107681) 1107681..1107941 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MNU28_RS05195 (1107947) 1107947..1108087 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MNU28_RS05200 (1108143) 1108143..1108613 - 471 WP_000136183.1 YlaC family protein -
MNU28_RS05205 (1108730) 1108730..1109281 - 552 WP_001278793.1 maltose O-acetyltransferase -
MNU28_RS05210 (1109460) 1109460..1109678 - 219 WP_001280991.1 HHA domain-containing protein Toxin
MNU28_RS05215 (1109706) 1109706..1110080 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MNU28_RS05220 (1110576) 1110576..1113725 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MNU28_RS05225 (1113748) 1113748..1114941 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238303 WP_001280991.1 NZ_CP093373:c1109678-1109460 [Salmonella enterica subsp. enterica serovar Infantis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238303 NZ_LR890299:3547917-3548024 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238303 WP_000344807.1 NZ_CP093373:c1110080-1109706 [Salmonella enterica subsp. enterica serovar Infantis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238303 NZ_LR890299:c3547859-3547805 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References