Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 443334..443850 Replicon chromosome
Accession NZ_CP093373
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag MNU28_RS02110 Protein ID WP_023993574.1
Coordinates 443566..443850 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag MNU28_RS02105 Protein ID WP_023993575.1
Coordinates 443334..443576 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS02085 (438354) 438354..439487 + 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -
MNU28_RS02090 (439471) 439471..440589 + 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MNU28_RS02095 (440586) 440586..441326 + 741 WP_023993577.1 KDGP aldolase family protein -
MNU28_RS02100 (441343) 441343..443256 + 1914 WP_023993576.1 BglG family transcription antiterminator -
MNU28_RS02105 (443334) 443334..443576 + 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MNU28_RS02110 (443566) 443566..443850 + 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNU28_RS02115 (443854) 443854..444318 - 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MNU28_RS02120 (444535) 444535..446673 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
MNU28_RS02125 (447082) 447082..448734 - 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T238299 WP_023993574.1 NZ_CP093373:443566-443850 [Salmonella enterica subsp. enterica serovar Infantis]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T238299 NZ_LR890299:c2777946-2777773 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT238299 WP_023993575.1 NZ_CP093373:443334-443576 [Salmonella enterica subsp. enterica serovar Infantis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp

>AT238299 NZ_LR890299:c2778270-2777974 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References