Detailed information of TA system TA238272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 783601..784415
• Replicon: chromosome
• Accession: NZ_CP093369
• Organism: Escherichia coli strain EV36 mutant 5a

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: L0Q35_RS03790
• Protein ID: WP_001054376.1
• Coordinates: 784158..784415 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: L0Q35_RS03785
• Protein ID: WP_001309181.1
• Coordinates: 783601..784146 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Q35_RS03755 (779292)	779292..780605	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
L0Q35_RS03760 (780617)	780617..780895	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
L0Q35_RS03765 (780892)	780892..782013	-	1122	WP_000010829.1	M42 family metallopeptidase	-
L0Q35_RS03770 (782258)	782258..782374	-	117	Protein_743	VOC family protein	-
L0Q35_RS03775 (782412)	782412..782630	-	219	Protein_744	hypothetical protein	-
L0Q35_RS03780 (782799)	782799..783545	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
L0Q35_RS03785 (783601)	783601..784146	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
L0Q35_RS03790 (784158)	784158..784415	-	258	WP_001054376.1	YjhX family toxin	Toxin
L0Q35_RS03795 (784906)	784906..785037	-	132	WP_001309182.1	hypothetical protein	-
L0Q35_RS03800 (785153)	785153..786393	+	1241	Protein_749	helicase YjhR	-
L0Q35_RS03805 (786661)	786661..786866	-	206	Protein_750	HNH endonuclease	-
L0Q35_RS03810 (786976)	786976..787956	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
L0Q35_RS03815 (788021)	788021..789127	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fimB / fimE	738923..792995	54072

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T238272 WP_001054376.1 NZ_CP093369:c784415-784158 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T238272 NZ_LR890291:710968-711453 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTAATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT238272 WP_001309181.1 NZ_CP093369:c784146-783601 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT238272 NZ_LR890291:710678-710971 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8