Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1268344..1268963 Replicon chromosome
Accession NC_012731
Organism Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KP1_RS06230 Protein ID WP_002892050.1
Coordinates 1268344..1268562 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KP1_RS06235 Protein ID WP_002892066.1
Coordinates 1268589..1268963 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP1_RS06195 1264385..1264648 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KP1_RS06200 1264648..1264788 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KP1_RS06205 1264785..1265483 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
KP1_RS06210 1265584..1267041 + 1458 WP_041937768.1 PLP-dependent aminotransferase family protein -
KP1_RS06215 1267016..1267486 - 471 WP_002892026.1 YlaC family protein -
KP1_RS29390 1267507..1267647 + 141 WP_004147370.1 hypothetical protein -
KP1_RS06225 1267619..1268185 - 567 WP_002892030.1 maltose O-acetyltransferase -
KP1_RS06230 1268344..1268562 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
KP1_RS06235 1268589..1268963 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KP1_RS06240 1269449..1272595 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KP1_RS06245 1272618..1273811 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T23824 WP_002892050.1 NC_012731:c1268562-1268344 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T23824 NC_012731:c1268562-1268344 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT23824 WP_002892066.1 NC_012731:c1268963-1268589 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT23824 NC_012731:c1268963-1268589 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References