Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 689313..689914 Replicon chromosome
Accession NZ_CP093365
Organism Bombilactobacillus thymidiniphilus strain SG4_A1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MOO47_RS03725 Protein ID WP_249513454.1
Coordinates 689313..689657 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MOO47_RS03730 Protein ID WP_249513455.1
Coordinates 689651..689914 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO47_RS03685 (MOO47_03685) 684720..685115 - 396 WP_249513446.1 DUF1310 family protein -
MOO47_RS03690 (MOO47_03690) 685196..685477 - 282 WP_249513447.1 hypothetical protein -
MOO47_RS03695 (MOO47_03695) 685482..685868 - 387 WP_249513448.1 DUF1310 family protein -
MOO47_RS03700 (MOO47_03700) 686038..686430 - 393 WP_249513449.1 DUF1310 family protein -
MOO47_RS03705 (MOO47_03705) 686577..686966 - 390 WP_249513450.1 DUF1310 family protein -
MOO47_RS03710 (MOO47_03710) 687149..687544 - 396 WP_249513451.1 DUF1310 family protein -
MOO47_RS03715 (MOO47_03715) 687695..688093 - 399 WP_249513452.1 DUF1310 family protein -
MOO47_RS03720 (MOO47_03720) 688475..689209 - 735 WP_249513453.1 choloylglycine hydrolase family protein -
MOO47_RS03725 (MOO47_03725) 689313..689657 - 345 WP_249513454.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MOO47_RS03730 (MOO47_03730) 689651..689914 - 264 WP_249513455.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MOO47_RS03735 (MOO47_03735) 690009..690587 + 579 WP_249513536.1 site-specific integrase -
MOO47_RS03740 (MOO47_03740) 690605..690793 + 189 WP_249513456.1 hypothetical protein -
MOO47_RS03745 (MOO47_03745) 690926..692833 + 1908 WP_249513537.1 DNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-101)

Antitoxin

Antitoxin PemI-like

(8-84)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13001.91 Da        Isoelectric Point: 6.7231

>T238237 WP_249513454.1 NZ_CP093365:c689657-689313 [Bombilactobacillus thymidiniphilus]
MVKQGDIFYVNFSPSRGHEQMYRRPAIALSHDMVAQTSNMTIVAPISSTTRDFPMYHQLTSSRNVYGKVLLDQTIALDLR
ARQVKNDDIVDQVTRAELVEIIDLYKLLFSIDPA

Download         Length: 345 bp

>T238237 NZ_LR890286:3878708-3878926 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9879.15 Da        Isoelectric Point: 5.0484

>AT238237 WP_249513455.1 NZ_CP093365:c689914-689651 [Bombilactobacillus thymidiniphilus]
MALIQAQTRLAKWGNSQAARIPSQIIKKLQLADNQELDVTVENGAIVLTPVRKQPANIHELFKDWHDDGIREHELDWGQA
TGDELPW

Download         Length: 264 bp

>AT238237 NZ_LR890286:3878307-3878681 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References