Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 5170235..5171130 Replicon chromosome
Accession NZ_CP093358
Organism Pseudomonas aeruginosa strain E167

Toxin (Protein)


Gene name slvT Uniprot ID A0A318E8F0
Locus tag MN180_RS24430 Protein ID WP_023093160.1
Coordinates 5170235..5170762 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A318DY98
Locus tag MN180_RS24435 Protein ID WP_023093161.1
Coordinates 5170759..5171130 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN180_RS24410 (MN180_24410) 5166028..5168043 - 2016 WP_023093157.1 DNA topoisomerase III -
MN180_RS24415 (MN180_24415) 5168338..5168721 - 384 WP_004362284.1 single-stranded DNA-binding protein -
MN180_RS24420 (MN180_24420) 5168718..5169266 - 549 WP_023093158.1 DUF3158 family protein -
MN180_RS24425 (MN180_24425) 5169263..5170051 - 789 WP_023093159.1 TIGR03761 family integrating conjugative element protein -
MN180_RS24430 (MN180_24430) 5170235..5170762 - 528 WP_023093160.1 RES family NAD+ phosphorylase Toxin
MN180_RS24435 (MN180_24435) 5170759..5171130 - 372 WP_023093161.1 hypothetical protein Antitoxin
MN180_RS24440 (MN180_24440) 5171251..5172444 - 1194 WP_023093162.1 STY4528 family pathogenicity island replication protein -
MN180_RS24445 (MN180_24445) 5172448..5173008 - 561 WP_023093163.1 DUF2857 domain-containing protein -
MN180_RS24450 (MN180_24450) 5173026..5174684 - 1659 WP_023093164.1 ParB family protein -
MN180_RS24455 (MN180_24455) 5174677..5174913 - 237 WP_012584779.1 hypothetical protein -
MN180_RS24460 (MN180_24460) 5174897..5175763 - 867 WP_023093165.1 ParA family protein -
MN180_RS24465 (MN180_24465) 5175804..5176022 - 219 WP_016446183.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5096293..5238930 142637


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19831.28 Da        Isoelectric Point: 5.2440

>T238235 WP_023093160.1 NZ_CP093358:c5170762-5170235 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Download         Length: 528 bp

>T238235 NZ_LR890286:1792078-1792180 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13358.05 Da        Isoelectric Point: 6.0705

>AT238235 WP_023093161.1 NZ_CP093358:c5171130-5170759 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Download         Length: 372 bp

>AT238235 NZ_LR890286:c1792187-1792042 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318E8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A318DY98

References