Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3722506..3723727 Replicon chromosome
Accession NZ_CP093358
Organism Pseudomonas aeruginosa strain E167

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MN180_RS17250 Protein ID WP_003160088.1
Coordinates 3723149..3723727 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MN180_RS17245 Protein ID WP_003088112.1
Coordinates 3722506..3723060 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN180_RS17220 (MN180_17220) 3718074..3718625 + 552 WP_003102727.1 XRE family transcriptional regulator -
MN180_RS17225 (MN180_17225) 3718622..3719020 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
MN180_RS17230 (MN180_17230) 3719033..3719356 - 324 WP_003102734.1 multidrug efflux SMR transporter -
MN180_RS17235 (MN180_17235) 3719687..3720148 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
MN180_RS17240 (MN180_17240) 3720153..3722348 + 2196 WP_003160090.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MN180_RS17245 (MN180_17245) 3722506..3723060 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
MN180_RS17250 (MN180_17250) 3723149..3723727 + 579 WP_003160088.1 HD domain-containing protein Toxin
MN180_RS17255 (MN180_17255) 3723836..3725023 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MN180_RS17260 (MN180_17260) 3725013..3727184 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
MN180_RS17265 (MN180_17265) 3727174..3728451 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T238233 WP_003160088.1 NZ_CP093358:3723149-3723727 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T238233 NZ_LR890286:322712-323080 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT238233 WP_003088112.1 NZ_CP093358:3722506-3723060 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT238233 NZ_LR890286:322494-322715 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References