Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
Location | 2416824..2417866 | Replicon | chromosome |
Accession | NZ_CP093358 | ||
Organism | Pseudomonas aeruginosa strain E167 |
Toxin (Protein)
Gene name | PP_4152 | Uniprot ID | - |
Locus tag | MN180_RS11345 | Protein ID | WP_003153636.1 |
Coordinates | 2417291..2417866 (+) | Length | 192 a.a. |
Antitoxin (Protein)
Gene name | PP_4151 | Uniprot ID | I3TV68 |
Locus tag | MN180_RS11340 | Protein ID | WP_003050245.1 |
Coordinates | 2416824..2417294 (+) | Length | 157 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MN180_RS11305 (MN180_11305) | 2412216..2413634 | - | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
MN180_RS11310 (MN180_11310) | 2413624..2414535 | - | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
MN180_RS11315 (MN180_11315) | 2414532..2415224 | - | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
MN180_RS11320 (MN180_11320) | 2415221..2415619 | - | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
MN180_RS11325 (MN180_11325) | 2415631..2415990 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
MN180_RS11330 (MN180_11330) | 2416007..2416240 | - | 234 | WP_003090170.1 | TIGR03758 family integrating conjugative element protein | - |
MN180_RS11335 (MN180_11335) | 2416237..2416620 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
MN180_RS11340 (MN180_11340) | 2416824..2417294 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
MN180_RS11345 (MN180_11345) | 2417291..2417866 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
MN180_RS11350 (MN180_11350) | 2417884..2418798 | + | 915 | WP_023114497.1 | AAA family ATPase | - |
MN180_RS11355 (MN180_11355) | 2418795..2419265 | + | 471 | WP_023114496.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
MN180_RS11360 (MN180_11360) | 2419262..2419762 | + | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
MN180_RS11365 (MN180_11365) | 2419762..2420664 | + | 903 | WP_003090158.1 | CBASS oligonucleotide cyclase | - |
MN180_RS11370 (MN180_11370) | 2420703..2421428 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 2342259..2463981 | 121722 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T238232 WP_003153636.1 NZ_CP093358:2417291-2417866 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T238232 NZ_LR890279:79181-79465 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT238232 WP_003050245.1 NZ_CP093358:2416824-2417294 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT238232 NZ_LR890279:78943-79191 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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