238232

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2416824..2417866 Replicon chromosome
Accession NZ_CP093358
Organism Pseudomonas aeruginosa strain E167

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag MN180_RS11345 Protein ID WP_003153636.1
Coordinates 2417291..2417866 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag MN180_RS11340 Protein ID WP_003050245.1
Coordinates 2416824..2417294 (+) Length 157 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN180_RS11305 (MN180_11305) 2412216..2413634 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
MN180_RS11310 (MN180_11310) 2413624..2414535 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
MN180_RS11315 (MN180_11315) 2414532..2415224 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
MN180_RS11320 (MN180_11320) 2415221..2415619 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
MN180_RS11325 (MN180_11325) 2415631..2415990 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
MN180_RS11330 (MN180_11330) 2416007..2416240 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
MN180_RS11335 (MN180_11335) 2416237..2416620 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
MN180_RS11340 (MN180_11340) 2416824..2417294 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
MN180_RS11345 (MN180_11345) 2417291..2417866 + 576 WP_003153636.1 PIN domain-containing protein Toxin
MN180_RS11350 (MN180_11350) 2417884..2418798 + 915 WP_023114497.1 AAA family ATPase -
MN180_RS11355 (MN180_11355) 2418795..2419265 + 471 WP_023114496.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
MN180_RS11360 (MN180_11360) 2419262..2419762 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
MN180_RS11365 (MN180_11365) 2419762..2420664 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
MN180_RS11370 (MN180_11370) 2420703..2421428 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2342259..2463981 121722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-114)

Antitoxin

(85-133)


Sequences


Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T238232 WP_003153636.1 NZ_CP093358:2417291-2417866 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T238232 NZ_LR890279:79181-79465 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT238232 WP_003050245.1 NZ_CP093358:2416824-2417294 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT238232 NZ_LR890279:78943-79191 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References