Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1305599..1306269 Replicon chromosome
Accession NZ_CP093358
Organism Pseudomonas aeruginosa strain E167

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MN180_RS06105 Protein ID WP_023114647.1
Coordinates 1305850..1306269 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MN180_RS06100 Protein ID WP_023114648.1
Coordinates 1305599..1305853 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN180_RS06080 (MN180_06080) 1301140..1302132 - 993 WP_023114651.1 hypothetical protein -
MN180_RS06085 (MN180_06085) 1302226..1302450 + 225 WP_023114650.1 AlpA family phage regulatory protein -
MN180_RS06090 (MN180_06090) 1302453..1303346 + 894 WP_031637438.1 helicase RepA family protein -
MN180_RS06095 (MN180_06095) 1303327..1304304 + 978 WP_031637437.1 replication protein C, IncQ-type -
MN180_RS06100 (MN180_06100) 1305599..1305853 + 255 WP_023114648.1 Arc family DNA-binding protein Antitoxin
MN180_RS06105 (MN180_06105) 1305850..1306269 + 420 WP_023114647.1 type II toxin-antitoxin system VapC family toxin Toxin
MN180_RS06110 (MN180_06110) 1306425..1307195 + 771 WP_023114646.1 P-type conjugative transfer protein TrbJ -
MN180_RS06115 (MN180_06115) 1307209..1307367 + 159 WP_023114645.1 hypothetical protein -
MN180_RS06120 (MN180_06120) 1307369..1308820 + 1452 WP_242145051.1 P-type conjugative transfer protein TrbL -
MN180_RS06125 (MN180_06125) 1308889..1309131 + 243 WP_023114643.1 type I toxin-antitoxin system ptaRNA1 family toxin -
MN180_RS06130 (MN180_06130) 1309143..1309427 + 285 WP_023114642.1 hypothetical protein -
MN180_RS06135 (MN180_06135) 1309430..1309798 + 369 WP_023114641.1 conjugal transfer transcriptional regulator TraJ -
MN180_RS06140 (MN180_06140) 1309837..1310067 - 231 WP_229033214.1 hypothetical protein -
MN180_RS06145 (MN180_06145) 1310047..1310295 - 249 Protein_1217 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1301140..1320730 19590


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14925.16 Da        Isoelectric Point: 5.1890

>T238230 WP_023114647.1 NZ_CP093358:1305850-1306269 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVVETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T238230 NZ_LR890278:c80720-80238 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9508.87 Da        Isoelectric Point: 6.4760

>AT238230 WP_023114648.1 NZ_CP093358:1305599-1305853 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT238230 NZ_LR890278:c80974-80708 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References