Detailed information of TA system TA238229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 148110..148615
• Replicon: chromosome
• Accession: NZ_CP093358
• Organism: Pseudomonas aeruginosa strain E167

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MN180_RS00680
• Protein ID: WP_023114790.1
• Coordinates: 148110..148391 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MN180_RS00685
• Protein ID: WP_003083775.1
• Coordinates: 148388..148615 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MN180_RS00655 (MN180_00655)	143361..144710	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
MN180_RS00660 (MN180_00660)	144759..145445	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MN180_RS00665 (MN180_00665)	145546..146280	+	735	WP_003117208.1	GntR family transcriptional regulator	-
MN180_RS00670 (MN180_00670)	146460..146870	+	411	WP_003101225.1	aegerolysin family protein	-
MN180_RS00675 (MN180_00675)	146902..147810	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MN180_RS00680 (MN180_00680)	148110..148391	-	282	WP_023114790.1	type II toxin-antitoxin system toxin ParE	Toxin
MN180_RS00685 (MN180_00685)	148388..148615	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MN180_RS00690 (MN180_00690)	148791..149411	-	621	WP_003101226.1	hypothetical protein	-
MN180_RS00695 (MN180_00695)	149512..150012	+	501	WP_003101228.1	LEA type 2 family protein	-
MN180_RS00700 (MN180_00700)	150085..150426	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MN180_RS00705 (MN180_00705)	150508..151935	-	1428	WP_003083784.1	GABA permease	-
MN180_RS00710 (MN180_00710)	152104..153597	-	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10464.21 Da
• Isoelectric Point: 10.0014

>T238229 WP_023114790.1 NZ_CP093358:c148391-148110 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Nucleotide

• Length: 282 bp

>T238229 NZ_LR890278:c60310-59894 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT238229 WP_003083775.1 NZ_CP093358:c148615-148388 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT238229 NZ_LR890278:c60537-60307 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9