Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 5088639..5089534 Replicon chromosome
Accession NZ_CP093357
Organism Pseudomonas aeruginosa strain E131

Toxin (Protein)


Gene name slvT Uniprot ID A0A318E8F0
Locus tag MN179_RS23830 Protein ID WP_023093160.1
Coordinates 5088639..5089166 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A318DY98
Locus tag MN179_RS23835 Protein ID WP_023093161.1
Coordinates 5089163..5089534 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN179_RS23810 (MN179_23810) 5084432..5086447 - 2016 WP_023093157.1 DNA topoisomerase III -
MN179_RS23815 (MN179_23815) 5086742..5087125 - 384 WP_004362284.1 single-stranded DNA-binding protein -
MN179_RS23820 (MN179_23820) 5087122..5087670 - 549 WP_023093158.1 DUF3158 family protein -
MN179_RS23825 (MN179_23825) 5087667..5088455 - 789 WP_023093159.1 TIGR03761 family integrating conjugative element protein -
MN179_RS23830 (MN179_23830) 5088639..5089166 - 528 WP_023093160.1 RES family NAD+ phosphorylase Toxin
MN179_RS23835 (MN179_23835) 5089163..5089534 - 372 WP_023093161.1 hypothetical protein Antitoxin
MN179_RS23840 (MN179_23840) 5089655..5090848 - 1194 WP_023093162.1 STY4528 family pathogenicity island replication protein -
MN179_RS23845 (MN179_23845) 5090852..5091412 - 561 WP_023093163.1 DUF2857 domain-containing protein -
MN179_RS23850 (MN179_23850) 5091430..5093088 - 1659 WP_023093164.1 ParB family protein -
MN179_RS23855 (MN179_23855) 5093081..5093317 - 237 WP_012584779.1 hypothetical protein -
MN179_RS23860 (MN179_23860) 5093301..5094167 - 867 WP_023093165.1 ParA family protein -
MN179_RS23865 (MN179_23865) 5094208..5094426 - 219 WP_016446183.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5079637..5098487 18850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19831.28 Da        Isoelectric Point: 5.2440

>T238227 WP_023093160.1 NZ_CP093357:c5089166-5088639 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Download         Length: 528 bp

>T238227 NZ_LR890277:c5041410-5041027 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13358.05 Da        Isoelectric Point: 6.0705

>AT238227 WP_023093161.1 NZ_CP093357:c5089534-5089163 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Download         Length: 372 bp

>AT238227 NZ_LR890277:c5041652-5041410 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318E8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A318DY98

References