Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 5088639..5089534 | Replicon | chromosome |
| Accession | NZ_CP093357 | ||
| Organism | Pseudomonas aeruginosa strain E131 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A318E8F0 |
| Locus tag | MN179_RS23830 | Protein ID | WP_023093160.1 |
| Coordinates | 5088639..5089166 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A318DY98 |
| Locus tag | MN179_RS23835 | Protein ID | WP_023093161.1 |
| Coordinates | 5089163..5089534 (-) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MN179_RS23810 (MN179_23810) | 5084432..5086447 | - | 2016 | WP_023093157.1 | DNA topoisomerase III | - |
| MN179_RS23815 (MN179_23815) | 5086742..5087125 | - | 384 | WP_004362284.1 | single-stranded DNA-binding protein | - |
| MN179_RS23820 (MN179_23820) | 5087122..5087670 | - | 549 | WP_023093158.1 | DUF3158 family protein | - |
| MN179_RS23825 (MN179_23825) | 5087667..5088455 | - | 789 | WP_023093159.1 | TIGR03761 family integrating conjugative element protein | - |
| MN179_RS23830 (MN179_23830) | 5088639..5089166 | - | 528 | WP_023093160.1 | RES family NAD+ phosphorylase | Toxin |
| MN179_RS23835 (MN179_23835) | 5089163..5089534 | - | 372 | WP_023093161.1 | hypothetical protein | Antitoxin |
| MN179_RS23840 (MN179_23840) | 5089655..5090848 | - | 1194 | WP_023093162.1 | STY4528 family pathogenicity island replication protein | - |
| MN179_RS23845 (MN179_23845) | 5090852..5091412 | - | 561 | WP_023093163.1 | DUF2857 domain-containing protein | - |
| MN179_RS23850 (MN179_23850) | 5091430..5093088 | - | 1659 | WP_023093164.1 | ParB family protein | - |
| MN179_RS23855 (MN179_23855) | 5093081..5093317 | - | 237 | WP_012584779.1 | hypothetical protein | - |
| MN179_RS23860 (MN179_23860) | 5093301..5094167 | - | 867 | WP_023093165.1 | ParA family protein | - |
| MN179_RS23865 (MN179_23865) | 5094208..5094426 | - | 219 | WP_016446183.1 | AlpA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 5079637..5098487 | 18850 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19831.28 Da Isoelectric Point: 5.2440
>T238227 WP_023093160.1 NZ_CP093357:c5089166-5088639 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR
Download Length: 528 bp
>T238227 NZ_LR890277:c5041410-5041027 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13358.05 Da Isoelectric Point: 6.0705
>AT238227 WP_023093161.1 NZ_CP093357:c5089534-5089163 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG
Download Length: 372 bp
>AT238227 NZ_LR890277:c5041652-5041410 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A318E8F0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A318DY98 |