Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3653905..3655126 Replicon chromosome
Accession NZ_CP093357
Organism Pseudomonas aeruginosa strain E131

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MN179_RS16830 Protein ID WP_003160088.1
Coordinates 3654548..3655126 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MN179_RS16825 Protein ID WP_003088112.1
Coordinates 3653905..3654459 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN179_RS16800 (MN179_16800) 3649473..3650024 + 552 WP_003102727.1 XRE family transcriptional regulator -
MN179_RS16805 (MN179_16805) 3650021..3650419 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
MN179_RS16810 (MN179_16810) 3650432..3650755 - 324 WP_003102734.1 multidrug efflux SMR transporter -
MN179_RS16815 (MN179_16815) 3651086..3651547 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
MN179_RS16820 (MN179_16820) 3651552..3653747 + 2196 WP_241940110.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MN179_RS16825 (MN179_16825) 3653905..3654459 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
MN179_RS16830 (MN179_16830) 3654548..3655126 + 579 WP_003160088.1 HD domain-containing protein Toxin
MN179_RS16835 (MN179_16835) 3655235..3656422 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MN179_RS16840 (MN179_16840) 3656412..3658583 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
MN179_RS16845 (MN179_16845) 3658573..3659850 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T238225 WP_003160088.1 NZ_CP093357:3654548-3655126 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T238225 NZ_LR890277:c4555830-4555546 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT238225 WP_003088112.1 NZ_CP093357:3653905-3654459 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT238225 NZ_LR890277:c4556062-4555820 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References