Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2814241..2815283 | Replicon | chromosome |
| Accession | NZ_CP093356 | ||
| Organism | Pseudomonas aeruginosa strain E125 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | MN178_RS13380 | Protein ID | WP_003050248.1 |
| Coordinates | 2814708..2815283 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | MN178_RS13375 | Protein ID | WP_003050245.1 |
| Coordinates | 2814241..2814711 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MN178_RS13340 (MN178_13340) | 2809632..2811050 | - | 1419 | WP_023087297.1 | TIGR03752 family integrating conjugative element protein | - |
| MN178_RS13345 (MN178_13345) | 2811040..2811951 | - | 912 | WP_023087298.1 | TIGR03749 family integrating conjugative element protein | - |
| MN178_RS13350 (MN178_13350) | 2811948..2812640 | - | 693 | WP_023087299.1 | TIGR03746 family integrating conjugative element protein | - |
| MN178_RS13355 (MN178_13355) | 2812637..2813035 | - | 399 | WP_003105639.1 | TIGR03750 family conjugal transfer protein | - |
| MN178_RS13360 (MN178_13360) | 2813048..2813407 | - | 360 | WP_021195311.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| MN178_RS13365 (MN178_13365) | 2813424..2813657 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| MN178_RS13370 (MN178_13370) | 2813654..2814037 | - | 384 | WP_023087300.1 | RAQPRD family integrative conjugative element protein | - |
| MN178_RS13375 (MN178_13375) | 2814241..2814711 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| MN178_RS13380 (MN178_13380) | 2814708..2815283 | + | 576 | WP_003050248.1 | PIN domain-containing protein | Toxin |
| MN178_RS13385 (MN178_13385) | 2815301..2816215 | + | 915 | WP_023087301.1 | AAA family ATPase | - |
| MN178_RS13390 (MN178_13390) | 2816212..2816682 | + | 471 | WP_023087302.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| MN178_RS13395 (MN178_13395) | 2816679..2817179 | + | 501 | WP_003050262.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| MN178_RS13400 (MN178_13400) | 2817179..2818081 | + | 903 | WP_023087303.1 | CBASS oligonucleotide cyclase | - |
| MN178_RS13405 (MN178_13405) | 2818118..2818843 | + | 726 | WP_023087304.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2745564..2860771 | 115207 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21630.76 Da Isoelectric Point: 5.6130
>T238216 WP_003050248.1 NZ_CP093356:2814708-2815283 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T238216 NZ_LR890274:2047-2328 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATGTCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATGTCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT238216 WP_003050245.1 NZ_CP093356:2814241-2814711 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT238216 NZ_LR890274:1781-2050 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTTCCGATAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTTCCGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|