Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1973301..1974809 Replicon chromosome
Accession NZ_CP093356
Organism Pseudomonas aeruginosa strain E125

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag MN178_RS09190 Protein ID WP_003119682.1
Coordinates 1973301..1973888 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7M2ZM82
Locus tag MN178_RS09195 Protein ID WP_023087137.1
Coordinates 1973955..1974809 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN178_RS09185 (MN178_09185) 1969556..1973035 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
MN178_RS09190 (MN178_09190) 1973301..1973888 + 588 WP_003119682.1 GNAT family protein Toxin
MN178_RS09195 (MN178_09195) 1973955..1974809 + 855 WP_023087137.1 AraC family transcriptional regulator Antitoxin
MN178_RS09200 (MN178_09200) 1974906..1977071 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
MN178_RS09205 (MN178_09205) 1977246..1979120 + 1875 WP_003117607.1 MFS transporter -
MN178_RS09210 (MN178_09210) 1979181..1979390 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T238214 WP_003119682.1 NZ_CP093356:1973301-1973888 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T238214 NZ_LR890273:c13033-12851 [Escherichia coli]
GTGAAGTATTCAGAGTTCAAACGCTGGTTAATCCAGCAAGGGGCAGAGTTCAGGAAAGCGCCTGGTGGCGGCAGTCATCA
GAAAGTGAACCTGAACGGAAAGCGGTCGGTTTTCCCGGACCACGGTTCAAAGGAAATGCCTGAACCGCTACGCAAGAAAA
TAATGAAGGACCTGGGGCTTTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31925.22 Da        Isoelectric Point: 7.5295

>AT238214 WP_023087137.1 NZ_CP093356:1973955-1974809 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHSGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT238214 NZ_LR890273:c12820-12389 [Escherichia coli]
ATGTTTAACTATCCGGTAAAACTGGAGCGCGACGACAAAACCGGCGCGTATGTCGTATCATGCCGCGACCTACCATTGTT
TAATTCCGTGGGTGACTCAGTTGAAGAAGCGTTGCTTGAGGCTGGTTATGGATTGGTCGCAGCGGTTGCGATTGAGATTG
AAGAACGCCGACCTGTTCCCACTGGTAGCGAGCCAAAAGAAGGTGAGTACGTTGTCTCTTTGCCAGTGCTACCAGCAATG
AAGGCTGCACTCCACAACGCGATGATAGAAACCGGCACACGCAAAGCAGAGTTGGCGCGCAAACTCGGAAAAAATGGAAC
ACAGATTGATCGGCTTCTCGACGTCGAACATTCATCGAAAGTTGAAACTGTCGAGCTGGCACTGCATCAACTGAATAAAA
ATATCGTCGTATCTGTCACACCAATGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2ZM82

References