Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 141168..141673 | Replicon | chromosome |
Accession | NZ_CP093356 | ||
Organism | Pseudomonas aeruginosa strain E125 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A7M2ZNP4 |
Locus tag | MN178_RS00640 | Protein ID | WP_009875660.1 |
Coordinates | 141168..141449 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A0H2ZJU8 |
Locus tag | MN178_RS00645 | Protein ID | WP_003137009.1 |
Coordinates | 141446..141673 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MN178_RS00615 (MN178_00615) | 136419..137768 | + | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
MN178_RS00620 (MN178_00620) | 137817..138503 | + | 687 | WP_004351997.1 | FadR/GntR family transcriptional regulator | - |
MN178_RS00625 (MN178_00625) | 138604..139338 | + | 735 | WP_003117208.1 | GntR family transcriptional regulator | - |
MN178_RS00630 (MN178_00630) | 139518..139928 | + | 411 | WP_003101225.1 | aegerolysin family protein | - |
MN178_RS00635 (MN178_00635) | 139960..140868 | - | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
MN178_RS00640 (MN178_00640) | 141168..141449 | - | 282 | WP_009875660.1 | type II toxin-antitoxin system toxin ParE | Toxin |
MN178_RS00645 (MN178_00645) | 141446..141673 | - | 228 | WP_003137009.1 | CopG family ribbon-helix-helix protein | Antitoxin |
MN178_RS00650 (MN178_00650) | 141849..142469 | - | 621 | WP_023086863.1 | hypothetical protein | - |
MN178_RS00655 (MN178_00655) | 142570..143070 | + | 501 | WP_003101228.1 | LEA type 2 family protein | - |
MN178_RS00660 (MN178_00660) | 143143..143484 | + | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
MN178_RS00665 (MN178_00665) | 143566..144993 | - | 1428 | WP_003083784.1 | GABA permease | - |
MN178_RS00670 (MN178_00670) | 145162..146655 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10461.25 Da Isoelectric Point: 10.4670
>T238213 WP_009875660.1 NZ_CP093356:c141449-141168 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLKRWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLKRWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T238213 NZ_LR890272:48563-48715 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8526.56 Da Isoelectric Point: 5.5740
>AT238213 WP_003137009.1 NZ_CP093356:c141673-141446 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ
Download Length: 228 bp
>AT238213 NZ_LR890272:c48508-48451 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7M2ZNP4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H2ZJU8 |