Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141168..141673 Replicon chromosome
Accession NZ_CP093356
Organism Pseudomonas aeruginosa strain E125

Toxin (Protein)


Gene name parE Uniprot ID A0A7M2ZNP4
Locus tag MN178_RS00640 Protein ID WP_009875660.1
Coordinates 141168..141449 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag MN178_RS00645 Protein ID WP_003137009.1
Coordinates 141446..141673 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN178_RS00615 (MN178_00615) 136419..137768 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
MN178_RS00620 (MN178_00620) 137817..138503 + 687 WP_004351997.1 FadR/GntR family transcriptional regulator -
MN178_RS00625 (MN178_00625) 138604..139338 + 735 WP_003117208.1 GntR family transcriptional regulator -
MN178_RS00630 (MN178_00630) 139518..139928 + 411 WP_003101225.1 aegerolysin family protein -
MN178_RS00635 (MN178_00635) 139960..140868 - 909 WP_003083769.1 LysR family transcriptional regulator -
MN178_RS00640 (MN178_00640) 141168..141449 - 282 WP_009875660.1 type II toxin-antitoxin system toxin ParE Toxin
MN178_RS00645 (MN178_00645) 141446..141673 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
MN178_RS00650 (MN178_00650) 141849..142469 - 621 WP_023086863.1 hypothetical protein -
MN178_RS00655 (MN178_00655) 142570..143070 + 501 WP_003101228.1 LEA type 2 family protein -
MN178_RS00660 (MN178_00660) 143143..143484 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
MN178_RS00665 (MN178_00665) 143566..144993 - 1428 WP_003083784.1 GABA permease -
MN178_RS00670 (MN178_00670) 145162..146655 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10461.25 Da        Isoelectric Point: 10.4670

>T238213 WP_009875660.1 NZ_CP093356:c141449-141168 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLKRWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T238213 NZ_LR890272:48563-48715 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT238213 WP_003137009.1 NZ_CP093356:c141673-141446 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT238213 NZ_LR890272:c48508-48451 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2ZNP4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References