Detailed information of TA system TA238211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4638202..4639460
• Replicon: chromosome
• Accession: NZ_CP093355
• Organism: Pseudomonas aeruginosa strain E104

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LRN73_RS21575
• Protein ID: WP_023114076.1
• Coordinates: 4638202..4638957 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: LRN73_RS21580
• Protein ID: WP_003086329.1
• Coordinates: 4639092..4639460 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRN73_RS21565 (LRN73_21565)	4633375..4635918	+	2544	WP_009315399.1	acyl-homoserine-lactone acylase QuiP	-
LRN73_RS21570 (LRN73_21570)	4636073..4637434	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
LRN73_RS21575 (LRN73_21575)	4638202..4638957	-	756	WP_023114076.1	RES family NAD+ phosphorylase	Toxin
LRN73_RS21580 (LRN73_21580)	4639092..4639460	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
LRN73_RS21585 (LRN73_21585)	4639533..4640819	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
LRN73_RS21590 (LRN73_21590)	4640875..4642368	-	1494	WP_023114075.1	aldehyde dehydrogenase family protein	-
LRN73_RS21595 (LRN73_21595)	4642543..4643019	+	477	WP_003134036.1	elongation factor GreAB	-
LRN73_RS21600 (LRN73_21600)	4643022..4643297	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28309.54 Da
• Isoelectric Point: 8.3428

>T238211 WP_023114076.1 NZ_CP093355:c4638957-4638202 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWKL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T238211 NZ_LR890271:c104869-104453 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT238211 WP_003086329.1 NZ_CP093355:c4639460-4639092 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT238211 NZ_LR890271:c105096-104866 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7