Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3724628..3725849 | Replicon | chromosome |
Accession | NZ_CP093355 | ||
Organism | Pseudomonas aeruginosa strain E104 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | LRN73_RS17265 | Protein ID | WP_003160088.1 |
Coordinates | 3725271..3725849 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | LRN73_RS17260 | Protein ID | WP_003088112.1 |
Coordinates | 3724628..3725182 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LRN73_RS17235 (LRN73_17235) | 3720196..3720747 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
LRN73_RS17240 (LRN73_17240) | 3720744..3721142 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
LRN73_RS17245 (LRN73_17245) | 3721155..3721478 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
LRN73_RS17250 (LRN73_17250) | 3721809..3722270 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
LRN73_RS17255 (LRN73_17255) | 3722275..3724470 | + | 2196 | WP_003160090.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
LRN73_RS17260 (LRN73_17260) | 3724628..3725182 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
LRN73_RS17265 (LRN73_17265) | 3725271..3725849 | + | 579 | WP_003160088.1 | HD domain-containing protein | Toxin |
LRN73_RS17270 (LRN73_17270) | 3725958..3727145 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
LRN73_RS17275 (LRN73_17275) | 3727135..3729306 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
LRN73_RS17280 (LRN73_17280) | 3729296..3730573 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21816.65 Da Isoelectric Point: 5.1625
>T238210 WP_003160088.1 NZ_CP093355:3725271-3725849 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
Download Length: 579 bp
>T238210 NZ_LR890271:c52432-52274 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT238210 WP_003088112.1 NZ_CP093355:3724628-3725182 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
>AT238210 NZ_LR890271:c52700-52476 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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