Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3724628..3725849 Replicon chromosome
Accession NZ_CP093355
Organism Pseudomonas aeruginosa strain E104

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRN73_RS17265 Protein ID WP_003160088.1
Coordinates 3725271..3725849 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LRN73_RS17260 Protein ID WP_003088112.1
Coordinates 3724628..3725182 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRN73_RS17235 (LRN73_17235) 3720196..3720747 + 552 WP_003102727.1 XRE family transcriptional regulator -
LRN73_RS17240 (LRN73_17240) 3720744..3721142 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LRN73_RS17245 (LRN73_17245) 3721155..3721478 - 324 WP_003102734.1 multidrug efflux SMR transporter -
LRN73_RS17250 (LRN73_17250) 3721809..3722270 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LRN73_RS17255 (LRN73_17255) 3722275..3724470 + 2196 WP_003160090.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LRN73_RS17260 (LRN73_17260) 3724628..3725182 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LRN73_RS17265 (LRN73_17265) 3725271..3725849 + 579 WP_003160088.1 HD domain-containing protein Toxin
LRN73_RS17270 (LRN73_17270) 3725958..3727145 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LRN73_RS17275 (LRN73_17275) 3727135..3729306 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
LRN73_RS17280 (LRN73_17280) 3729296..3730573 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T238210 WP_003160088.1 NZ_CP093355:3725271-3725849 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T238210 NZ_LR890271:c52432-52274 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT238210 WP_003088112.1 NZ_CP093355:3724628-3725182 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT238210 NZ_LR890271:c52700-52476 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References