Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1305713..1306383 Replicon chromosome
Accession NZ_CP093355
Organism Pseudomonas aeruginosa strain E104

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRN73_RS06105 Protein ID WP_023114647.1
Coordinates 1305964..1306383 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LRN73_RS06100 Protein ID WP_023114648.1
Coordinates 1305713..1305967 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRN73_RS06080 (LRN73_06080) 1301254..1302246 - 993 WP_023114651.1 hypothetical protein -
LRN73_RS06085 (LRN73_06085) 1302340..1302564 + 225 WP_023114650.1 AlpA family phage regulatory protein -
LRN73_RS06090 (LRN73_06090) 1302567..1303460 + 894 WP_031637438.1 helicase RepA family protein -
LRN73_RS06095 (LRN73_06095) 1303441..1304418 + 978 WP_031637437.1 replication protein C, IncQ-type -
LRN73_RS06100 (LRN73_06100) 1305713..1305967 + 255 WP_023114648.1 Arc family DNA-binding protein Antitoxin
LRN73_RS06105 (LRN73_06105) 1305964..1306383 + 420 WP_023114647.1 type II toxin-antitoxin system VapC family toxin Toxin
LRN73_RS06110 (LRN73_06110) 1306539..1307309 + 771 WP_023114646.1 P-type conjugative transfer protein TrbJ -
LRN73_RS06115 (LRN73_06115) 1307323..1307481 + 159 WP_023114645.1 hypothetical protein -
LRN73_RS06120 (LRN73_06120) 1307483..1308955 + 1473 WP_023114644.1 P-type conjugative transfer protein TrbL -
LRN73_RS06125 (LRN73_06125) 1309024..1309266 + 243 WP_023114643.1 type I toxin-antitoxin system ptaRNA1 family toxin -
LRN73_RS06130 (LRN73_06130) 1309278..1309562 + 285 WP_023114642.1 hypothetical protein -
LRN73_RS06135 (LRN73_06135) 1309565..1309933 + 369 WP_023114641.1 conjugal transfer transcriptional regulator TraJ -
LRN73_RS06140 (LRN73_06140) 1309972..1310202 - 231 WP_229033214.1 hypothetical protein -
LRN73_RS06145 (LRN73_06145) 1310182..1310430 - 249 Protein_1217 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1301254..1320865 19611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14925.16 Da        Isoelectric Point: 5.1890

>T238207 WP_023114647.1 NZ_CP093355:1305964-1306383 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVVETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T238207 NZ_LR890270:c4847337-4846843 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9508.87 Da        Isoelectric Point: 6.4760

>AT238207 WP_023114648.1 NZ_CP093355:1305713-1305967 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT238207 NZ_LR890270:c4847627-4847334 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References