Detailed information of TA system TA238206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 148156..148661
• Replicon: chromosome
• Accession: NZ_CP093355
• Organism: Pseudomonas aeruginosa strain E104

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LRN73_RS00680
• Protein ID: WP_023114790.1
• Coordinates: 148156..148437 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: LRN73_RS00685
• Protein ID: WP_003083775.1
• Coordinates: 148434..148661 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRN73_RS00655 (LRN73_00655)	143407..144756	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
LRN73_RS00660 (LRN73_00660)	144805..145491	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
LRN73_RS00665 (LRN73_00665)	145592..146326	+	735	WP_003117208.1	GntR family transcriptional regulator	-
LRN73_RS00670 (LRN73_00670)	146506..146916	+	411	WP_003101225.1	aegerolysin family protein	-
LRN73_RS00675 (LRN73_00675)	146948..147856	-	909	WP_196636187.1	LysR substrate-binding domain-containing protein	-
LRN73_RS00680 (LRN73_00680)	148156..148437	-	282	WP_023114790.1	type II toxin-antitoxin system toxin ParE	Toxin
LRN73_RS00685 (LRN73_00685)	148434..148661	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
LRN73_RS00690 (LRN73_00690)	148837..149457	-	621	WP_003101226.1	hypothetical protein	-
LRN73_RS00695 (LRN73_00695)	149558..150058	+	501	WP_003101228.1	LEA type 2 family protein	-
LRN73_RS00700 (LRN73_00700)	150131..150472	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
LRN73_RS00705 (LRN73_00705)	150554..151981	-	1428	WP_003083784.1	GABA permease	-
LRN73_RS00710 (LRN73_00710)	152150..153643	-	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10464.21 Da
• Isoelectric Point: 10.0014

>T238206 WP_023114790.1 NZ_CP093355:c148437-148156 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Nucleotide

• Length: 282 bp

>T238206 NZ_LR890270:c4604594-4604208 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT238206 WP_003083775.1 NZ_CP093355:c148661-148434 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT238206 NZ_LR890270:c4604218-4603889 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9