Detailed information of TA system TA238203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3814578..3815799
• Replicon: chromosome
• Accession: NZ_CP093354
• Organism: Pseudomonas aeruginosa strain E113

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: MN130_RS17660
• Protein ID: WP_003102740.1
• Coordinates: 3815221..3815799 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MN130_RS17655
• Protein ID: WP_003088112.1
• Coordinates: 3814578..3815132 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MN130_RS17630 (MN130_17630)	3810146..3810697	+	552	WP_003450159.1	XRE family transcriptional regulator	-
MN130_RS17635 (MN130_17635)	3810694..3811092	-	399	WP_023089053.1	NADH-quinone oxidoreductase subunit A	-
MN130_RS17640 (MN130_17640)	3811105..3811428	-	324	WP_023119961.1	multidrug efflux SMR transporter	-
MN130_RS17645 (MN130_17645)	3811759..3812220	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MN130_RS17650 (MN130_17650)	3812225..3814420	+	2196	WP_031755310.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MN130_RS17655 (MN130_17655)	3814578..3815132	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MN130_RS17660 (MN130_17660)	3815221..3815799	+	579	WP_003102740.1	HD domain-containing protein	Toxin
MN130_RS17665 (MN130_17665)	3815908..3817095	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MN130_RS17670 (MN130_17670)	3817085..3819256	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
MN130_RS17675 (MN130_17675)	3819246..3820523	-	1278	WP_003122808.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T238203 WP_003102740.1 NZ_CP093354:3815221-3815799 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T238203 NZ_LR890270:3931822-3932220 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGTGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT238203 WP_003088112.1 NZ_CP093354:3814578-3815132 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT238203 NZ_LR890270:3931526-3931819 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07