Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 176126..176631 Replicon chromosome
Accession NZ_CP093354
Organism Pseudomonas aeruginosa strain E113

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag MN130_RS00820 Protein ID WP_003121619.1
Coordinates 176126..176407 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag MN130_RS00825 Protein ID WP_003112628.1
Coordinates 176404..176631 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MN130_RS00795 (MN130_00795) 171377..172726 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
MN130_RS00800 (MN130_00800) 172775..173461 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
MN130_RS00805 (MN130_00805) 173562..174296 + 735 WP_003117208.1 GntR family transcriptional regulator -
MN130_RS00810 (MN130_00810) 174476..174886 + 411 WP_003101225.1 aegerolysin family protein -
MN130_RS00815 (MN130_00815) 174918..175826 - 909 WP_016561475.1 LysR family transcriptional regulator -
MN130_RS00820 (MN130_00820) 176126..176407 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
MN130_RS00825 (MN130_00825) 176404..176631 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
MN130_RS00830 (MN130_00830) 176807..177427 - 621 WP_003101226.1 hypothetical protein -
MN130_RS00835 (MN130_00835) 177528..178028 + 501 WP_003112629.1 LEA type 2 family protein -
MN130_RS00840 (MN130_00840) 178101..178442 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
MN130_RS00845 (MN130_00845) 178524..179951 - 1428 WP_003083784.1 GABA permease -
MN130_RS00850 (MN130_00850) 180120..181613 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T238200 WP_003121619.1 NZ_CP093354:c176407-176126 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T238200 NZ_LR890270:3369032-3369382 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT238200 WP_003112628.1 NZ_CP093354:c176631-176404 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT238200 NZ_LR890270:3368787-3369038 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References