Detailed information of TA system TA023820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 2093409..2093988
• Replicon: chromosome
• Accession: NC_012726
• Organism: Sulfolobus islandicus M.16.4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C4KKM6
• Locus tag: M164_RS11455
• Protein ID: WP_012719090.1
• Coordinates: 2093584..2093988 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C4KKM5
• Locus tag: M164_RS11450
• Protein ID: WP_012712236.1
• Coordinates: 2093409..2093603 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M164_RS11420 (M164_2279)	2088758..2089633	+	876	WP_012736141.1	ABC transporter ATP-binding protein	-
M164_RS11425 (M164_2280)	2089624..2090241	+	618	WP_012712231.1	hypothetical protein	-
M164_RS11430 (M164_2281)	2090238..2090624	+	387	WP_009989099.1	hypothetical protein	-
M164_RS11435 (M164_2282)	2090621..2091286	-	666	WP_009989098.1	helix-turn-helix domain-containing protein	-
M164_RS11440 (M164_2283)	2091405..2092676	-	1272	WP_012736142.1	MFS transporter	-
M164_RS11445 (M164_2284)	2092731..2093018	-	288	WP_012736143.1	EamA family transporter	-
M164_RS14750 (M164_2285)	2093121..2093333	-	213	WP_049780006.1	hypothetical protein	-
M164_RS11450 (M164_2286)	2093409..2093603	+	195	WP_012712236.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
M164_RS11455 (M164_2287)	2093584..2093988	+	405	WP_012719090.1	PIN domain-containing protein	Toxin
M164_RS14490 (M164_2288)	2094184..2095066	-	883	Protein_2306	IS110 family transposase	-
M164_RS11470 (M164_2289)	2095551..2096330	-	780	WP_016732287.1	DMT family transporter	-
M164_RS11475 (M164_2291)	2097166..2097348	+	183	WP_009990866.1	hypothetical protein	-
M164_RS11480 (M164_2292)	2097496..2098257	+	762	WP_009990867.1	ZIP family metal transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (6-39)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15314.84 Da
• Isoelectric Point: 5.0349

>T23820 WP_012719090.1 NC_012726:2093584-2093988 [Sulfolobus islandicus M.16.4]
VEKAIVDTSVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMSFLKGMKLEDKVDDVLAYSRSEKAEVVCDCTDNV
IDAIGVLKKEKLPLISYKNMVILSHAIREKLPLATFDRELSKIAKKYSVSLLQS

Nucleotide

• Length: 405 bp

>T23820 NC_012726:2093584-2093988 [Sulfolobus islandicus M.16.4]
GTGGAGAAGGCAATAGTTGACACTAGCGTGATAATTTACGACTACGTTGAAGACTCCGAATATCATAAGAGGGCTGAAGA
GCTTCTCGATAGTTTGGATAGGTGGGTAATTCCCGTGATTGTAGTTCATGAGATCATGTCGTTCTTAAAGGGCATGAAAC
TTGAAGACAAGGTAGATGACGTTTTGGCTTATAGTAGAAGTGAGAAAGCTGAGGTTGTGTGCGATTGTACAGATAACGTC
ATTGACGCTATAGGAGTGCTGAAGAAGGAAAAGCTTCCCTTGATCAGCTACAAAAATATGGTAATACTTTCTCACGCAAT
TAGAGAAAAATTGCCTTTAGCCACTTTTGATAGGGAACTCTCAAAGATAGCAAAGAAGTACTCCGTAAGTTTGCTACAGT
CGTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7122.17 Da
• Isoelectric Point: 8.6155

>AT23820 WP_012712236.1 NC_012726:2093409-2093603 [Sulfolobus islandicus M.16.4]
MIKSTPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGNKLSLGDIEEAIERGEGNS

Nucleotide

• Length: 195 bp

>AT23820 NC_012726:2093409-2093603 [Sulfolobus islandicus M.16.4]
TTGATTAAGAGCACTCCAGCCTCGGCTAGGAGTAAGATTAATATAAAAGAAGGAGATATACTTGAGGTTTACTTGAACGG
TGACGAGATAGTACTTCGGAAGGTTAAGACTGAGAGGCCGAGGATAAGGCTAGGCAATAAACTCTCACTGGGAGATATTG
AGGAGGCAATAGAGCGTGGAGAAGGCAATAGTTGA

Structures

Toxin

• AlphaFold DB: C4KKM6

Antitoxin

• AlphaFold DB: C4KKM5