Detailed information of TA system TA238198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2734463..2735946
• Replicon: chromosome
• Accession: NZ_CP093337
• Organism: Shinella sp. H4-D48

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: MNR02_RS13515
• Protein ID: WP_241947161.1
• Coordinates: 2734684..2735946 (+)
• Length: 421 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: MNR02_RS13510
• Protein ID: WP_241947160.1
• Coordinates: 2734463..2734687 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNR02_RS13485 (MNR02_13485)	2729781..2731190	+	1410	WP_241947158.1	DHA2 family efflux MFS transporter permease subunit	-
MNR02_RS13490 (MNR02_13490)	2731196..2731579	-	384	WP_241604941.1	VOC family protein	-
MNR02_RS13495 (MNR02_13495)	2731579..2732295	-	717	WP_241604943.1	RlmE family RNA methyltransferase	-
MNR02_RS13500 (MNR02_13500)	2732292..2733839	-	1548	WP_241947159.1	Ppx/GppA phosphatase family protein	-
MNR02_RS13510 (MNR02_13510)	2734463..2734687	+	225	WP_241947160.1	helix-turn-helix domain-containing protein	Antitoxin
MNR02_RS13515 (MNR02_13515)	2734684..2735946	+	1263	WP_241947161.1	type II toxin-antitoxin system HipA family toxin	Toxin
MNR02_RS13520 (MNR02_13520)	2735977..2736159	-	183	WP_241947162.1	hypothetical protein	-
MNR02_RS13525 (MNR02_13525)	2736429..2736929	+	501	WP_241947163.1	hypothetical protein	-
MNR02_RS13530 (MNR02_13530)	2737015..2737857	+	843	WP_241947164.1	DUF3102 domain-containing protein	-
MNR02_RS13535 (MNR02_13535)	2738144..2739418	+	1275	WP_241947165.1	hypothetical protein	-
MNR02_RS13540 (MNR02_13540)	2739645..2740388	-	744	WP_241947166.1	SprT family zinc-dependent metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-66)

Sequences

Toxin

Protein

• Length: 421 a.a.
• Molecular weight: 45704.62 Da
• Isoelectric Point: 5.5224

>T238198 WP_241947161.1 NZ_CP093337:2734684-2735946 [Shinella sp. H4-D48]
MSRVLDVFLKDRKAGELKQDSDASLTFAYDGDYLASDPIALSVSLPVREEPFADRVARPFFSGLLPDEGARRRLAAALGI
SSGNAFGLLEVIGGECAGALSLVPPGQFPPASTTDDAEALDEQLLEGILSLLRQRPLLGGEGDVRLSLAGAQDKLAVTVI
NGHILLPRGGRPTTHILKPFIEGLDGTVENEVFCMSLGRRLGLDVPAVSKGTAGKVDYFLVERYDRLTLEDGRIERLHQE
DFCQALSVPPELKYEEEGGPGISQCLQLIRQTTAKPAAETLRFQRMLMFHYLIGNADAHAKNYALLYRGKAPDLAPMYDA
ICTAAYPRLSKKMAMALGGRSLPDTIQMEHWASLVPSNKAATRMLAGELVRMADAIGLEADGLMDEMSENGTYHPILKTV
RKIIDTRCALMRRAVEKPSL

Nucleotide

• Length: 1263 bp

>T238198 NZ_LR890270:c2635615-2635430 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCTATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7785.96 Da
• Isoelectric Point: 10.7087

>AT238198 WP_241947160.1 NZ_CP093337:2734463-2734687 [Shinella sp. H4-D48]
MATVSDSVALGQLIRAERKRQQLTQEQLAGVAGVGVRFVRELESGKESCRVGLALTVLQTLGLTVSITSRGASS

Nucleotide

• Length: 225 bp

>AT238198 NZ_LR890270:c2635413-2635003 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA