Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 983567..984053 Replicon chromosome
Accession NZ_CP093337
Organism Shinella sp. H4-D48

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag MNR02_RS04690 Protein ID WP_241948263.1
Coordinates 983784..984053 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag MNR02_RS04685 Protein ID WP_241948262.1
Coordinates 983567..983800 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNR02_RS04670 (MNR02_04670) 979050..980138 + 1089 WP_134646944.1 hypothetical protein -
MNR02_RS04675 (MNR02_04675) 980389..981537 + 1149 WP_241948260.1 hypothetical protein -
MNR02_RS04680 (MNR02_04680) 981587..983497 + 1911 WP_241948261.1 AAA family ATPase -
MNR02_RS04685 (MNR02_04685) 983567..983800 + 234 WP_241948262.1 DUF6290 family protein Antitoxin
MNR02_RS04690 (MNR02_04690) 983784..984053 + 270 WP_241948263.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNR02_RS04695 (MNR02_04695) 984072..985373 + 1302 WP_241948264.1 hypothetical protein -
MNR02_RS04700 (MNR02_04700) 985366..986514 + 1149 WP_241948265.1 DUF2333 family protein -
MNR02_RS04705 (MNR02_04705) 986735..988414 + 1680 WP_241948266.1 formate--tetrahydrofolate ligase -
MNR02_RS04710 (MNR02_04710) 988453..988959 - 507 WP_241948267.1 DUF1993 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10182.84 Da        Isoelectric Point: 10.1380

>T238197 WP_241948263.1 NZ_CP093337:983784-984053 [Shinella sp. H4-D48]
MAWAIEITEGAKKELDKLGHVEAKRILNFLVTKLASSENPRLLGSALQGARLGSYWRYRVGDYRIICDIQDNRLVVVVVR
VGHRREIYS

Download         Length: 270 bp

>T238197 NZ_LR890270:2161285-2161749 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8994.96 Da        Isoelectric Point: 4.3633

>AT238197 WP_241948262.1 NZ_CP093337:983567-983800 [Shinella sp. H4-D48]
MARQTAIRLPDETYERLQALAARTGRTATYYIREAIEQHIEDLEDIYLAEQELEHVRRGESRVYSLKEVEDELGLGD

Download         Length: 234 bp

>AT238197 NZ_LR890270:2160950-2161285 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References