Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1401847..1402421 Replicon chromosome
Accession NZ_CP093335
Organism Sphingopyxis granuli strain A2-E30

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MNQ96_RS06590 Protein ID WP_067181744.1
Coordinates 1401847..1402140 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MNQ96_RS06595 Protein ID WP_241942780.1
Coordinates 1402137..1402421 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ96_RS06575 (MNQ96_06575) 1397709..1398584 - 876 WP_241942777.1 prolipoprotein diacylglyceryl transferase -
MNQ96_RS06580 (MNQ96_06580) 1398661..1400367 + 1707 WP_241942778.1 class I adenylate-forming enzyme family protein -
MNQ96_RS06585 (MNQ96_06585) 1400563..1401804 + 1242 WP_241942779.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
MNQ96_RS06590 (MNQ96_06590) 1401847..1402140 + 294 WP_067181744.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNQ96_RS06595 (MNQ96_06595) 1402137..1402421 + 285 WP_241942780.1 putative addiction module antidote protein Antitoxin
MNQ96_RS06600 (MNQ96_06600) 1402570..1403808 + 1239 WP_241942781.1 mechanosensitive ion channel -
MNQ96_RS06605 (MNQ96_06605) 1404146..1405363 + 1218 WP_067113208.1 argininosuccinate synthase -
MNQ96_RS06610 (MNQ96_06610) 1405556..1405774 + 219 WP_067181756.1 hypothetical protein -
MNQ96_RS06615 (MNQ96_06615) 1405824..1406825 + 1002 WP_241943225.1 beta-eliminating lyase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-90)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10702.32 Da        Isoelectric Point: 10.6041

>T238193 WP_067181744.1 NZ_CP093335:1401847-1402140 [Sphingopyxis granuli]
MIEIRRTDDFIQWIAGLRDVAARARIAKRLNRLATGNSGDVKSVGGGVSELRFTFGPGYRVYFTRRGDVVVILLCGGDKG
SQSRDIEKAKAMAKEIE

Download         Length: 294 bp

>T238193 NZ_LR890270:825456-825830 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10421.95 Da        Isoelectric Point: 4.6437

>AT238193 WP_241942780.1 NZ_CP093335:1402137-1402421 [Sphingopyxis granuli]
MMAIETRIWDPAELLRTPEDIAAYLDTYLEDGDSEEIREALRTIARSQGMTALARKTGLTREALYKALGENGNPTLDTLV
RICRALGLRLSLAA

Download         Length: 285 bp

>AT238193 NZ_LR890270:824999-825367 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References