Detailed information of TA system TA023819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 912372..912975
• Replicon: chromosome
• Accession: NC_012726
• Organism: Sulfolobus islandicus M.16.4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C4KG62
• Locus tag: M164_RS04765
• Protein ID: WP_012710993.1
• Coordinates: 912586..912975 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M9UC56
• Locus tag: M164_RS04760
• Protein ID: WP_012710994.1
• Coordinates: 912372..912599 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M164_RS04725 (M164_0958)	907651..908181	+	531	WP_012710999.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
M164_RS04730 (M164_0959)	908313..909050	-	738	WP_012735823.1	CorA family divalent cation transporter	-
M164_RS04735 (M164_0960)	909116..909334	-	219	Protein_964	IS1 family transposase	-
M164_RS04740 (M164_0961)	909461..909871	-	411	WP_012710997.1	PIN domain-containing protein	-
M164_RS04745 (M164_0962)	909868..910113	-	246	WP_012710996.1	hypothetical protein	-
M164_RS04750 (M164_0963)	910520..910837	+	318	WP_012710995.1	AAA family ATPase	-
M164_RS04755 (M164_0964)	910983..912030	+	1048	Protein_968	ISH3 family transposase	-
M164_RS04760 (M164_0965)	912372..912599	+	228	WP_012710994.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
M164_RS04765 (M164_0966)	912586..912975	+	390	WP_012710993.1	PIN domain-containing protein	Toxin
M164_RS14195	913373..913477	-	105	Protein_971	IS5/IS1182 family transposase	-
M164_RS04770 (M164_0967)	913764..913934	+	171	Protein_972	IS110 family transposase	-
M164_RS14200 (M164_0968)	914277..915425	-	1149	Protein_973	RNA-guided endonuclease TnpB family protein	-
M164_RS04785 (M164_0970)	916130..916507	+	378	WP_228375605.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• SpoVT-AbrB domain (3-47)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14829.41 Da
• Isoelectric Point: 4.7430

>T23819 WP_012710993.1 NC_012726:912586-912975 [Sulfolobus islandicus M.16.4]
MIVVDTNILVYSTFEDSENHSKALEIIEKEDVKIPQIVVYEFLWVLAKLTSDVSLIKTKIEELREFEIICENPETILNGV
KMLKEDGKPLKMLNDYVILALAKELKGDLATYDEKLRKIAEKHGVRIIP

Nucleotide

• Length: 390 bp

>T23819 NC_012726:912586-912975 [Sulfolobus islandicus M.16.4]
ATGATAGTAGTTGATACGAACATATTAGTTTATTCAACTTTTGAAGATTCCGAAAACCATTCTAAAGCTCTAGAAATTAT
AGAAAAGGAGGACGTTAAAATTCCGCAGATAGTCGTTTATGAGTTCTTATGGGTTTTAGCTAAACTTACATCAGATGTTT
CCTTAATAAAAACTAAGATTGAAGAGTTAAGAGAGTTTGAAATTATATGCGAAAACCCGGAAACCATACTCAATGGTGTA
AAAATGTTAAAGGAAGACGGTAAACCTTTAAAGATGTTAAATGATTACGTTATTCTAGCCTTAGCTAAGGAATTAAAAGG
AGATTTAGCAACCTATGATGAAAAATTAAGGAAAATTGCTGAAAAACATGGTGTAAGAATAATTCCTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8668.92 Da
• Isoelectric Point: 5.1486

>AT23819 WP_012710994.1 NC_012726:912372-912599 [Sulfolobus islandicus M.16.4]
MKVKVTRNFQVTIPSEIREKLGIKEGDYVEVTLDESNGTMIIKPYIRKWTTIRLNKKVDQEDIDKAVEEALNDSS

Nucleotide

• Length: 228 bp

>AT23819 NC_012726:912372-912599 [Sulfolobus islandicus M.16.4]
ATGAAAGTAAAGGTTACTAGAAACTTTCAAGTTACTATACCCTCAGAGATAAGAGAAAAATTAGGTATAAAGGAAGGAGA
TTATGTCGAAGTAACTTTGGATGAAAGTAATGGAACTATGATAATTAAGCCGTATATAAGAAAGTGGACTACAATAAGGT
TAAATAAAAAAGTAGACCAAGAGGATATAGATAAGGCAGTTGAGGAGGCACTAAATGATAGTAGTTGA

Structures

Toxin

• AlphaFold DB: C4KG62

Antitoxin

• AlphaFold DB: M9UC56