Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 4314434..4315160 Replicon chromosome
Accession NZ_CP093334
Organism Raoultella planticola strain A2-F21

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag MNO12_RS20785 Protein ID WP_241950342.1
Coordinates 4314434..4314763 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MNO12_RS20790 Protein ID WP_241950343.1
Coordinates 4314801..4315160 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO12_RS20775 (MNO12_20775) 4312258..4313433 - 1176 WP_241950341.1 efflux RND transporter periplasmic adaptor subunit -
MNO12_RS20780 (MNO12_20780) 4313767..4314120 + 354 WP_032696824.1 helix-turn-helix domain-containing protein -
MNO12_RS20785 (MNO12_20785) 4314434..4314763 - 330 WP_241950342.1 TA system toxin CbtA family protein Toxin
MNO12_RS20790 (MNO12_20790) 4314801..4315160 - 360 WP_241950343.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MNO12_RS20795 (MNO12_20795) 4315183..4315404 - 222 WP_241950344.1 DUF987 domain-containing protein -
MNO12_RS20800 (MNO12_20800) 4315419..4315898 - 480 WP_241950345.1 DNA repair protein RadC -
MNO12_RS20805 (MNO12_20805) 4315910..4316380 - 471 WP_241950346.1 antirestriction protein -
MNO12_RS20810 (MNO12_20810) 4316396..4316650 - 255 WP_072035668.1 hypothetical protein -
MNO12_RS20815 (MNO12_20815) 4316650..4317468 - 819 Protein_4075 DUF932 domain-containing protein -
MNO12_RS20820 (MNO12_20820) 4317566..4317799 - 234 WP_241950347.1 DUF905 family protein -
MNO12_RS20825 (MNO12_20825) 4317893..4318729 - 837 WP_241950348.1 hypothetical protein -
MNO12_RS20830 (MNO12_20830) 4319033..4319260 - 228 WP_042893214.1 hypothetical protein -
MNO12_RS20835 (MNO12_20835) 4319333..4319740 - 408 WP_241950349.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12466.21 Da        Isoelectric Point: 10.5232

>T238181 WP_241950342.1 NZ_CP093334:c4314763-4314434 [Raoultella planticola]
MQTLSSHSTRATQPNLSLVKTWQRLLTHLLSQHYGLRLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T238181 NZ_LR890254:4217505-4217789 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13411.25 Da        Isoelectric Point: 6.2032

>AT238181 WP_241950343.1 NZ_CP093334:c4315160-4314801 [Raoultella planticola]
MQNTTPVANHDIAEPWWGLKPTVTPCLGARLVQEGNRLHYLADPASITGTFNNEDLRHLDQAFPVLLKQLELMLVSGELT
SRYQHRITLYHNRLTCEADTLGSCGYVCIAIYPNQPEPH

Download         Length: 360 bp

>AT238181 NZ_LR890254:4217273-4217515 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References