238175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4090429..4091051 Replicon chromosome
Accession NZ_CP093332
Organism Buttiauxella ferragutiae strain H4-C11

Toxin (Protein)


Gene name Hha Uniprot ID A0A3G2IEF5
Locus tag MNO13_RS18830 Protein ID WP_064549071.1
Coordinates 4090833..4091051 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3G2ICZ8
Locus tag MNO13_RS18825 Protein ID WP_064549070.1
Coordinates 4090429..4090803 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO13_RS18815 (MNO13_18815) 4085502..4086701 + 1200 WP_064549066.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MNO13_RS18820 (MNO13_18820) 4086724..4089873 + 3150 WP_064549068.1 multidrug efflux RND transporter permease subunit AcrB -
MNO13_RS18825 (MNO13_18825) 4090429..4090803 + 375 WP_064549070.1 Hha toxicity modulator TomB Antitoxin
MNO13_RS18830 (MNO13_18830) 4090833..4091051 + 219 WP_064549071.1 HHA domain-containing protein Toxin
MNO13_RS18835 (MNO13_18835) 4091247..4091813 + 567 WP_064549075.1 maltose O-acetyltransferase -
MNO13_RS18840 (MNO13_18840) 4091916..4092374 + 459 WP_064549077.1 YlaC family protein -
MNO13_RS18845 (MNO13_18845) 4092414..4092554 - 141 WP_034458060.1 type B 50S ribosomal protein L36 -
MNO13_RS18850 (MNO13_18850) 4092849..4093886 + 1038 WP_064549079.1 isopenicillin N synthase family oxygenase -
MNO13_RS18855 (MNO13_18855) 4093905..4094714 + 810 WP_064549081.1 MetQ/NlpA family ABC transporter substrate-binding protein -
MNO13_RS18860 (MNO13_18860) 4094711..4095502 + 792 WP_241939138.1 methionine ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8611.01 Da        Isoelectric Point: 8.9108

>T238175 WP_064549071.1 NZ_CP093332:4090833-4091051 [Buttiauxella ferragutiae]
MTTKPLTKTDYLMRLRRCQTIETLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWTFIR

Download         Length: 219 bp

>T238175 NZ_LR890246:53921-54403 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14521.28 Da        Isoelectric Point: 4.9132

>AT238175 WP_064549070.1 NZ_CP093332:4090429-4090803 [Buttiauxella ferragutiae]
MDEYSPKRHDIAQLKFLCENLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAAFALNYKIKYDDESKLIEQIDEYL
DDTFMLFSNYGINAHDLQKWRKSGNRLFRCFVTESRANPVSLSF

Download         Length: 375 bp

>AT238175 NZ_LR890246:53667-53933 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2IEF5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2ICZ8

References