Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3983774..3984429 Replicon chromosome
Accession NZ_CP093332
Organism Buttiauxella ferragutiae strain H4-C11

Toxin (Protein)


Gene name vapC Uniprot ID A0A3G2IDJ0
Locus tag MNO13_RS18400 Protein ID WP_064548895.1
Coordinates 3983774..3984163 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3G2ICR3
Locus tag MNO13_RS18405 Protein ID WP_064548897.1
Coordinates 3984166..3984429 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO13_RS18365 (MNO13_18365) 3979321..3980502 + 1182 WP_241939111.1 FMN-dependent L-lactate dehydrogenase LldD -
MNO13_RS18370 (MNO13_18370) 3980546..3980848 - 303 WP_064548886.1 hypothetical protein -
MNO13_RS18375 (MNO13_18375) 3980838..3981167 - 330 WP_064548888.1 type II toxin-antitoxin system RelE/ParE family toxin -
MNO13_RS18380 (MNO13_18380) 3981383..3981811 - 429 WP_121814153.1 OsmC family protein -
MNO13_RS18385 (MNO13_18385) 3981970..3982503 + 534 WP_241939112.1 tetratricopeptide repeat protein -
MNO13_RS18390 (MNO13_18390) 3982582..3983031 + 450 WP_241940082.1 RNA polymerase sigma factor -
MNO13_RS18395 (MNO13_18395) 3983028..3983777 + 750 WP_241939113.1 anti-sigma factor -
MNO13_RS18400 (MNO13_18400) 3983774..3984163 - 390 WP_064548895.1 type II toxin-antitoxin system VapC family toxin Toxin
MNO13_RS18405 (MNO13_18405) 3984166..3984429 - 264 WP_064548897.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MNO13_RS18410 (MNO13_18410) 3984689..3984970 - 282 WP_064548899.1 acetolactate synthase small subunit -
MNO13_RS18415 (MNO13_18415) 3984974..3986662 - 1689 WP_133522378.1 acetolactate synthase large subunit -
MNO13_RS18420 (MNO13_18420) 3986773..3986871 - 99 WP_074388597.1 ilvB operon leader peptide IvbL -
MNO13_RS18425 (MNO13_18425) 3987000..3988022 - 1023 WP_232886114.1 GTP-binding protein -
MNO13_RS18430 (MNO13_18430) 3988038..3988235 - 198 WP_034456870.1 YbdD/YjiX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14403.59 Da        Isoelectric Point: 9.7107

>T238174 WP_064548895.1 NZ_CP093332:c3984163-3983774 [Buttiauxella ferragutiae]
MYMLDTNTVSYLFRQHPKVIEKLAQTRPVEVCISSVTEAELLYGVAKRQSKNLAAAVQGFLETVSVYAWDSEAAKSYGQL
RAAMEKKGKVLGHLDQLIAAHALSRNATVVTSDRAFTMVGRLRVEDWTR

Download         Length: 390 bp

>T238174 NZ_LR890245:c5229392-5229009 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10009.36 Da        Isoelectric Point: 8.5606

>AT238174 WP_064548897.1 NZ_CP093332:c3984429-3984166 [Buttiauxella ferragutiae]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRKDKEGNVILSKNPAKPEGWGNVFALVKKAKVPDNFLDEQERNQSIADR
DPFAGMD

Download         Length: 264 bp

>AT238174 NZ_LR890245:c5229634-5229392 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2IDJ0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2ICR3

References