Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2972591..2973168 Replicon chromosome
Accession NZ_CP093332
Organism Buttiauxella ferragutiae strain H4-C11

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MNO13_RS13685 Protein ID WP_241938893.1
Coordinates 2972591..2972923 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A3G2I9E0
Locus tag MNO13_RS13690 Protein ID WP_064547184.1
Coordinates 2972923..2973168 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO13_RS13665 (MNO13_13665) 2968405..2969931 + 1527 WP_241938892.1 p-aminobenzoyl-glutamate transporter -
MNO13_RS13670 (MNO13_13670) 2969944..2970459 + 516 WP_064547177.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
MNO13_RS13675 (MNO13_13675) 2970660..2971412 + 753 WP_064547179.1 fumarate/nitrate reduction transcriptional regulator Fnr -
MNO13_RS13680 (MNO13_13680) 2971549..2972499 + 951 WP_064547181.1 universal stress protein UspE -
MNO13_RS13685 (MNO13_13685) 2972591..2972923 - 333 WP_241938893.1 endoribonuclease MazF Toxin
MNO13_RS13690 (MNO13_13690) 2972923..2973168 - 246 WP_064547184.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MNO13_RS13695 (MNO13_13695) 2973266..2973772 - 507 WP_064547185.1 4-hydroxyphenylacetate 3-monooxygenase reductase subunit -
MNO13_RS13700 (MNO13_13700) 2973792..2975354 - 1563 WP_064547186.1 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component -
MNO13_RS13705 (MNO13_13705) 2975663..2975950 - 288 WP_232886859.1 type VI secretion system PAAR protein -
MNO13_RS13710 (MNO13_13710) 2975991..2976932 - 942 WP_241938894.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-106)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11974.75 Da        Isoelectric Point: 7.1064

>T238173 WP_241938893.1 NZ_CP093332:c2972923-2972591 [Buttiauxella ferragutiae]
MVSRFVPDSGDVIWIDFDHVAGHEQGGNRPAVVLSPFAYNNKVGLLLCVPCTTKAKDYPFEVELSGERESVALADQITCV
DWRARKVTKKGSVSVAELADIRAKAKTLIG

Download         Length: 333 bp

>T238173 NZ_LR890245:c4911990-4911073 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8713.15 Da        Isoelectric Point: 4.9849

>AT238173 WP_064547184.1 NZ_CP093332:c2973168-2972923 [Buttiauxella ferragutiae]
MSKVIVKKWGNSPSVRLPVAIMQAASLNVDDTVDISVEDGRIVIVPVKTKEYSLDALLAGITPDNIHEKVDFGAPVGKEL
I

Download         Length: 246 bp

>AT238173 NZ_LR890245:c4912754-4911996 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2I9E0

References