Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2708936..2709690 Replicon chromosome
Accession NZ_CP093332
Organism Buttiauxella ferragutiae strain H4-C11

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MNO13_RS12525 Protein ID WP_232885866.1
Coordinates 2709190..2709690 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag MNO13_RS12520 Protein ID WP_237931104.1
Coordinates 2708936..2709199 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO13_RS12500 (MNO13_12500) 2704164..2705780 + 1617 WP_241938799.1 aldehyde dehydrogenase (NADP(+)) -
MNO13_RS12505 (MNO13_12505) 2705801..2707366 + 1566 WP_064546695.1 APC family permease -
MNO13_RS12510 (MNO13_12510) 2707387..2708397 + 1011 WP_241938800.1 Ldh family oxidoreductase -
MNO13_RS12515 (MNO13_12515) 2708510..2708737 + 228 WP_064546700.1 hypothetical protein -
MNO13_RS12520 (MNO13_12520) 2708936..2709199 + 264 WP_237931104.1 DUF1778 domain-containing protein Antitoxin
MNO13_RS12525 (MNO13_12525) 2709190..2709690 + 501 WP_232885866.1 GNAT family N-acetyltransferase Toxin
MNO13_RS12530 (MNO13_12530) 2709809..2709979 - 171 WP_157092953.1 hypothetical protein -
MNO13_RS12535 (MNO13_12535) 2710087..2710722 - 636 WP_237931108.1 hypothetical protein -
MNO13_RS12540 (MNO13_12540) 2711183..2711476 - 294 WP_064546708.1 DUF1330 domain-containing protein -
MNO13_RS12545 (MNO13_12545) 2711515..2711838 - 324 WP_237931110.1 hypothetical protein -
MNO13_RS12550 (MNO13_12550) 2711974..2712363 - 390 WP_241938801.1 tautomerase family protein -
MNO13_RS12555 (MNO13_12555) 2712609..2713664 + 1056 WP_083963377.1 LysR family transcriptional regulator -
MNO13_RS12560 (MNO13_12560) 2713894..2714316 - 423 WP_241938802.1 DUF2809 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(48-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18268.04 Da        Isoelectric Point: 9.0406

>T238172 WP_232885866.1 NZ_CP093332:2709190-2709690 [Buttiauxella ferragutiae]
VGLVTAPEPLTSSHQLAEFVSGESVLDDWLKQRGLKNHAYGAARTFVICKKESKQVAGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVADNIGVRAIMVHALTEEAKQFYIHHGFKPLQTQERTLFFKLP
KDVEGT

Download         Length: 501 bp

>T238172 NZ_LR890245:c4750285-4750001 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10006.42 Da        Isoelectric Point: 4.6313

>AT238172 WP_237931104.1 NZ_CP093332:2708936-2709199 [Buttiauxella ferragutiae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPLSDDPAVKKLL
ARKPQWD

Download         Length: 264 bp

>AT238172 NZ_LR890245:c4750517-4750275 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References